Department of Neurosurgery, Taikang Ningbo Hospital, Ningbo, China.
Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
BMC Neurol. 2024 May 30;24(1):181. doi: 10.1186/s12883-024-03686-0.
Spinal cord malignant melanotic schwannoma (MMNST) is a rare central nervous system tumor that originates from the spinal cord or spinal myelin sheath cells and can produce melanin. This type of tumor is usually highly aggressive and malignant, with a poor prognosis. The clinical manifestations of spinal cord MMNST are mainly pain, paresthesia, muscle weakness, muscle atrophy, etc., and symptoms of spinal cord compression, such as intestinal and bladder dysfunction, paraplegia, etc. Early detection of tumor lesions can facilitate tumor removal, improve patients' quality of life, and prolong patients' survival. In this case report, a 27-year-old young woman was diagnosed with MMNST of the cervical spinal cord due to weakness of her limbs in our hospital, and underwent surgical resection. The patient's limbs returned to normal after surgery. It is worth mentioning that the patient visited our hospital 7 months ago for "right upper limb pain for 3 days" and was diagnosed with a cervical spine space-occupying lesion at the same position this time, but the pathology report was "hemosiderosis". The patient's limbs returned to normal after surgery. It is worth mentioning that the patient visited our hospital 7 months ago for "right upper limb pain for 3 days" and was diagnosed with a cervical spine space-occupying lesion at the same position this time, but the pathology report was "hemosiderosis". This case report aims to raise awareness of the problem of spinal cord MMNST and contribute to greater knowledge of this rare tumor. This case report aims to raise awareness of the problem of spinal cord MMNST and contribute to greater knowledge of this rare tumor.
脊髓恶性黑色素性神经鞘瘤(MMNST)是一种罕见的中枢神经系统肿瘤,起源于脊髓或脊髓髓鞘细胞,可产生黑色素。这种类型的肿瘤通常具有高度侵袭性和恶性,预后不良。脊髓 MMNST 的临床表现主要为疼痛、感觉异常、肌无力、肌肉萎缩等,以及脊髓压迫症状,如肠和膀胱功能障碍、截瘫等。早期发现肿瘤病变有利于肿瘤切除,提高患者生活质量,延长患者生存时间。本病例报告中,1 名 27 岁年轻女性因四肢无力在我院诊断为颈段脊髓 MMNST,并接受了手术切除。患者术后四肢恢复正常。值得注意的是,该患者 7 个月前因“右上肢疼痛 3 天”就诊我院,此次同样部位诊断为颈椎占位性病变,但病理报告为“含铁血黄素沉着症”。患者术后四肢恢复正常。值得注意的是,该患者 7 个月前因“右上肢疼痛 3 天”就诊我院,此次同样部位诊断为颈椎占位性病变,但病理报告为“含铁血黄素沉着症”。本病例报告旨在提高对脊髓 MMNST 问题的认识,并为了解这种罕见肿瘤做出贡献。