Wang Qing, Liu Xiao-Wei, Chen Ke-Yu
Department of Critical Care Medicine, Chengdu First People's Hospital, Chengdu 610000, Sichuan Province, China.
Department of Neurosurgery, Chengdu Second People's Hospital, Chengdu 610017, Sichuan Province, China.
World J Clin Cases. 2024 May 26;12(15):2597-2605. doi: 10.12998/wjcc.v12.i15.2597.
Pituitary gland metastasis is an unusual event, and pituitary metastasis from lung adenocarcinoma is extremely rare and associated with poor prognosis. To date, approximately 15 cases have been reported.
Here, we present the case of a 64-year-old woman with pituitary metastasis derived from lung adenocarcinoma, which was difficult to distinguish from other sellar tumors. The patient presented to the neurosurgery clinic with blurred vision and intermittent headache. During hospitalization, brain computed tomography (CT) and magnetic resonance imaging revealed a pituitary macroadenoma. Chest CT revealed irregular nodules in the basal segment of the lower lobe of the left lung, which were likely lung cancer. Positron emission tomography-CT revealed a carbohydrate metabolism tumor in the lungs and sellar region, which was considered malignant. Postoperative pathological examination of the sellar tumor revealed lung adenocarcinoma.
Excision of pituitary metastases combined with radiotherapy and chemotherapy should be a priority treatment for patients with pituitary metastasis.
垂体转移是一种不常见的情况，肺腺癌导致的垂体转移极为罕见且预后不良。迄今为止，已报道约15例病例。
在此，我们报告一例64岁女性，患有源自肺腺癌的垂体转移瘤，该肿瘤难以与其他鞍区肿瘤相鉴别。患者因视力模糊和间歇性头痛就诊于神经外科门诊。住院期间，脑部计算机断层扫描（CT）和磁共振成像显示为垂体大腺瘤。胸部CT显示左肺下叶基底段有不规则结节，可能为肺癌。正电子发射断层扫描-CT显示肺部和鞍区有糖代谢肿瘤，考虑为恶性。鞍区肿瘤术后病理检查显示为肺腺癌。
对于垂体转移患者，优先治疗方案应为切除垂体转移瘤并联合放化疗。
