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微小RNA多态性影响胃癌预后：来自福建仙游的见解

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian.

作者信息

Wu Ping, Zhang Yuling, Lyu Yanping, Chen Jingwen, Jiang Yu, Xiang Jianjun, Liu Baoying, Wu Chuancheng

机构信息

Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China.

Department of Pulmonary and Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

出版信息

Front Oncol. 2024 May 15;14:1355270. doi: 10.3389/fonc.2024.1355270. eCollection 2024.

DOI:10.3389/fonc.2024.1355270
PMID:38817897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11138161/
Abstract

INTRODUCTION

Gastric cancer, characterized by high incidence and substantial disease burden, has drawn continuous attention regarding its occurrence and prognosis. Genetics plays a crucial role in influencing the prognosis of gastric cancer, and single nucleotide polymorphisms are closely associated with the occurrence, development, and prognosis of this malignant tumor. Our study aims to conduct survival analysis on patients carrying different single nucleotide polymorphisms, exploring the relationship between miRNA single nucleotide polymorphisms and the prognosis of gastric cancer.

METHODS

Genetic data from 344 patients in Xianyou, Fujian, formed the basis of our study. We delineated the survival rate and median survival time, utilizing the log-rank test and COX regression analysis as statistical tools.

RESULTS

Upon stratifying the data by sex or operation, it was discerned that the GG genotype at MSH2 rs17502941 independently posed a heightened risk for gastric cancer. Other stratification analyses suggested that the subsequent single nucleotide polymorphisms were correlated with patient prognosis: rs17502941, rs884225, rs1468063, rs7143252, and rs2271738.

DISCUSSION

The outcomes of this study strongly suggest that miRNA polymorphisms significantly influence the survival time of gastric cancer patients and can serve as effective predictors for the prognosis of gastric cancer.

摘要

引言

胃癌发病率高且疾病负担重，其发生和预后一直备受关注。遗传学在影响胃癌预后方面起着关键作用，单核苷酸多态性与这种恶性肿瘤的发生、发展及预后密切相关。我们的研究旨在对携带不同单核苷酸多态性的患者进行生存分析，探索微小RNA单核苷酸多态性与胃癌预后之间的关系。

方法

来自福建仙游的344例患者的基因数据构成了我们研究的基础。我们利用对数秩检验和COX回归分析作为统计工具，描绘了生存率和中位生存时间。

结果

按性别或手术情况对数据进行分层后发现，MSH2 rs17502941位点的GG基因型独立地使胃癌风险增加。其他分层分析表明，后续的单核苷酸多态性与患者预后相关：rs17502941、rs884225、rs1468063、rs7143252和rs2271738。

讨论

本研究结果强烈表明，微小RNA多态性显著影响胃癌患者的生存时间，可作为胃癌预后的有效预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e21/11138161/840f81b35fbc/fonc-14-1355270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e21/11138161/51846552cfce/fonc-14-1355270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e21/11138161/4d1322906ad1/fonc-14-1355270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e21/11138161/840f81b35fbc/fonc-14-1355270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e21/11138161/51846552cfce/fonc-14-1355270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e21/11138161/4d1322906ad1/fonc-14-1355270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e21/11138161/840f81b35fbc/fonc-14-1355270-g003.jpg

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