Arnold R, Calvo W, Heymer B, Schmeiser T, Heimpel H, Kubanek B
Scand J Haematol. 1985 Jan;34(1):9-12. doi: 10.1111/j.1600-0609.1985.tb00736.x.
44 patients underwent bone marrow transplantation (BMT) for treatment of severe aplastic anaemia or haematological malignancies. During their post-transplant phase all patients had erythroblasts and granulocytic precursors in their peripheral blood. 15 patients died between day +6 and +346 after BMT and autopsies were performed. The sections of all 15 patients revealed extramedullary haemopoiesis in the spleen. Extramedullary haemopoiesis in the liver was found only in those patients who died early (between d +6 and d +21 after BMT). Medullary haemopoiesis, normally only occurring in the vertebral body, was also observed in the shaft of the femur. The present data show that after BMT all tissues with a haemopoietic matrix in ontogenesis can be repopulated with haemopoiesis in the early phase of reconstitution, possibly to compensate for the haemopoietic insufficiency after conditioning therapy. The expansion of haemopoiesis in the later period of up to 1 year after BMT, remains to be explained.
44例患者接受了骨髓移植（BMT）以治疗严重再生障碍性贫血或血液系统恶性肿瘤。在移植后的阶段，所有患者外周血中均出现了成红细胞和粒细胞前体。15例患者在BMT后第6天至第346天之间死亡，并进行了尸检。所有15例患者的切片均显示脾脏中有髓外造血。仅在早期死亡的患者（BMT后第6天至第21天之间）的肝脏中发现了髓外造血。通常仅发生在椎体中的骨髓造血，在股骨干中也有观察到。目前的数据表明，BMT后，所有在个体发育过程中具有造血基质的组织在重建的早期阶段都可以重新进行造血，这可能是为了补偿预处理治疗后的造血不足。BMT后长达1年的后期造血扩展情况仍有待解释。
