Tanaka T, Yamamoto M, Tamura T, Moritani Y, Miyai M, Hiraki S, Ohnoshi T, Kimura I
Acta Cytol. 1985 Jan-Feb;29(1):49-56.
The accuracy of cytologic diagnosis and typing was examined in 154 patients, 113 males and 41 females, who underwent radical surgery during the past six years. There were 42 central and 112 peripheral lesions: 6 adenocarcinomas and 28 squamous-cell carcinomas were centrally located and 69 adenocarcinomas and 27 squamous-cell carcinomas were peripherally located. Repetition of sputum sampling at least three times was preferred, especially in central lesions, which were detected in 57% to 64% of the cases by either three-day-pooled or aerosol-induced specimens. Peripheral lesions required brushing to enhance the accuracy. The overall typing accuracy was 64.3%, ranging from 83.6% in squamous-cell carcinoma to 25.0% in large-cell carcinoma. Cytologic positivity correlated well with the finding of tumors more than 3 cm in diameter. Adenocarcinoma and squamous-cell carcinoma showed no significant difference in frequency of regional lymph nodal metastases. The value of judging the accuracy of cytologic diagnosis and typing on the histologic evaluation of the entire resected lesion, rather than on biopsy specimens, is emphasized.
对过去六年中接受根治性手术的154例患者（113例男性和41例女性）的细胞学诊断及分型准确性进行了检查。有42例中央型病变和112例周围型病变：6例腺癌和28例鳞状细胞癌位于中央，69例腺癌和27例鳞状细胞癌位于周围。最好至少重复痰标本采样三次，尤其是中央型病变，通过三日痰池或雾化诱导标本在57%至64%的病例中检测到。周围型病变需要刷检以提高准确性。总体分型准确率为64.3%，从鳞状细胞癌的83.6%到大细胞癌的25.0%不等。细胞学阳性与直径大于3 cm的肿瘤发现密切相关。腺癌和鳞状细胞癌在区域淋巴结转移频率上无显著差异。强调了根据整个切除病变的组织学评估而非活检标本判断细胞学诊断及分型准确性的价值。
