Balment R J, Carrick S
Am J Physiol. 1985 Feb;248(2 Pt 2):R157-60. doi: 10.1152/ajpregu.1985.248.2.R157.
High rates of drinking in seawater-adapted, compared with freshwater (FW)-adapted, flounder were associated with raised plasma chloride and osmotic concentrations. Hypotension in FW-adapted fish, after papaverine administration, gave rise to greatly elevated rates of drinking. This dipsogenic response apparently relied on activation of the endogenous renin-angiotensin system (RAS) and was abolished by simultaneous administration of the converting enzyme inhibitor, captopril. Exogenous angiotensin II was shown to be dipsogenic and vasopressor in the FW-adapted fish. The physiological importance of the activation of the RAS in the control of drinking behavior in euryhaline fish is discussed.
与适应淡水（FW）的比目鱼相比，适应海水的比目鱼的高饮水率与血浆氯化物和渗透压浓度升高有关。给适应淡水的鱼注射罂粟碱后出现的低血压导致饮水率大幅升高。这种致渴反应显然依赖于内源性肾素-血管紧张素系统（RAS）的激活，并且通过同时给予转化酶抑制剂卡托普利而被消除。已证明外源性血管紧张素II在适应淡水的鱼中具有致渴和升压作用。本文讨论了RAS激活在广盐性鱼类饮水行为控制中的生理重要性。
