Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
PLoS One. 2024 May 31;19(5):e0304499. doi: 10.1371/journal.pone.0304499. eCollection 2024.
Tobacco-specific nitrosamines (TSNAs) are a group of toxic substances specific to tobacco. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a tobacco-specific nitrosamine measurable in urine with a much longer half-life than cotinine. We aimed to examine the association between urinary tobacco-specific NNAL and HPV infection among American women. We used cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2014 to collect details on their urinary NNAL, HPV infection status, and other essential variables. The association between dietary urinary NNAL and HPV infection status was analyzed by using a weighted multivariate logistic regression model, and stratified subgroup analysis. In total, 5197 participants aged 18-59 years were identified, with overall prevalence of high-risk and low-risk HPV infection of 22.0% and 19.1%, respectively. The highest quartile of NNAL(Q4) was more positively associated with low-risk HPV infection than the lowest quartile of NNAL(Q1) (OR = 1.83 (1.35,2.50), p<0.001). the highest quartile of NNAL(Q4) was more positively associated with high-risk HPV infection than the lowest quartile of NNAL(Q1) (OR = 2.20 (1.57,3.08), p < 0.001). In subgroup analyses, the positive correlation between urinary NNAL levels and low-risk HPV infection status was inconsistent in marital status and BMI (interaction p < 0.05). The positive association of urinary NNAL levels with high-risk HPV infection status was inconsistent in smoking and BMI. (interaction p < 0.05). Tobacco-specific NNAL levels positively correlate with high- and low-risk HPV. Future well-designed longitudinal studies are still needed to validate the effect of tobacco exposure on HPV infection by NNAL.
烟草特异性亚硝胺（TSNAs）是一组特定于烟草的有毒物质。4-（甲基亚硝氨基）-1-（3-吡啶基）-1-丁醇（NNAL）是一种可在尿液中测量的烟草特异性亚硝胺，其半衰期比可替宁长得多。我们旨在研究美国女性尿液中烟草特异性 NNAL 与 HPV 感染之间的关系。我们使用 2007 年至 2014 年期间进行的国家健康和营养检查调查（NHANES）的横断面数据，收集有关尿液 NNAL、HPV 感染状况和其他重要变量的详细信息。使用加权多变量逻辑回归模型和分层亚组分析来分析膳食尿液 NNAL 与 HPV 感染状况之间的关联。共确定了 5197 名年龄在 18-59 岁的参与者，高危型和低危型 HPV 感染的总患病率分别为 22.0%和 19.1%。NNAL 最高四分位数（Q4）与低危型 HPV 感染的相关性比 NNAL 最低四分位数（Q1）更为正相关（OR=1.83（1.35，2.50），p<0.001）。NNAL 最高四分位数（Q4）与高危型 HPV 感染的相关性比 NNAL 最低四分位数（Q1）更为正相关（OR=2.20（1.57，3.08），p<0.001）。在亚组分析中，尿液 NNAL 水平与低危型 HPV 感染状态之间的正相关性在婚姻状况和 BMI 方面不一致（交互 p<0.05）。尿液 NNAL 水平与高危型 HPV 感染状态之间的正相关性在吸烟和 BMI 方面不一致（交互 p<0.05）。烟草特异性 NNAL 水平与高危型和低危型 HPV 呈正相关。未来仍需要设计良好的纵向研究来验证 NNAL 暴露对 HPV 感染的影响。
