Zawada E T, Johnson M, Mackenzie T, Sica D A, Muakkassa W, Green S J, Goldman M
Arch Intern Med. 1985 Jan;145(1):82-4.
Studies were undertaken to determine levels of hemoglobin A1 in renal and heart transplant recipients. Hemoglobin A1 was measured by separation from Hb A using an affinity-column chromatography system. Significantly elevated levels of Hb A1 were found in all renal transplant patients; diabetic transplant recipients had the highest levels. There was no correlation between serum creatinine and Hb A1 levels in these transplant recipients. The Hb A1 level did correlate with the prior level of glycemia in these patients. Our findings raised the specter of the consequences of disturbed carbohydrate metabolism in these patients as not being different than that observed with other forms of end-stage renal disease management. Finally, in both diabetic and nondiabetic renal transplant recipients, measurement of Hb A1 can serve as a useful adjunct to assess prior glycemia when such information is not available to the clinician.
开展了多项研究以确定肾移植和心脏移植受者的糖化血红蛋白A1水平。使用亲和柱色谱系统通过与血红蛋白A分离来测量糖化血红蛋白A1。在所有肾移植患者中均发现糖化血红蛋白A1水平显著升高；糖尿病移植受者的水平最高。在这些移植受者中，血清肌酐与糖化血红蛋白A1水平之间没有相关性。糖化血红蛋白A1水平与这些患者先前的血糖水平相关。我们的研究结果引发了对这些患者碳水化合物代谢紊乱后果的担忧，其与其他形式的终末期肾病管理中观察到的情况并无不同。最后，在糖尿病和非糖尿病肾移植受者中，当临床医生无法获得此类信息时，测量糖化血红蛋白A1可作为评估先前血糖水平的有用辅助手段。
