Department of Dermatology, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an 710000, China; Department of Dermatology, Shaanxi Traditional Chinese Medicine Hospital, Xi'an 710000, China.
Department of Dermatology, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an 710000, China.
Photodiagnosis Photodyn Ther. 2024 Aug;48:104227. doi: 10.1016/j.pdpdt.2024.104227. Epub 2024 May 29.
Dissecting cellulitis of the scalp (DCS) has a significant impact on the physical well-being and body image of the patient. Since DCS often responds poorly to conventional treatments, there is a need to identify alternative treatment strategies. This study aimed to explore the effectiveness of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating DCS.
Twelve male patients with DCS treated solely with ALA-PDT between June 2022 and June 2023 at our institution were enrolled in this study. Two patients underwent a biopsy before and after treatment for comparison. The efficacy of the treatments was assessed 10 days after treatment by evaluating the symptom scores recorded on medical records and by assessing the photographs acquired before and after treatment. In addition, the impact of the treatment on pain relief and median recurrence rate were also extracted.
Out of the 12 enrolled patients, the majority of the patients (75%) had a significant reduction in the nodules or abscesses. The pain relief was significant in 3 patients (25%), and moderate in 7 patients (58.3%). For the subcutaneous sinus tract symptoms, 3 patients (27.3%) showed moderate improvement, and 7 (63.6%) had a mild improvement. Six patients (75%) had mild improvement in their alopecia. The pathology results showed a decrease in the number of lymphocytes, macrophages, and neutrophils within the skin lesions following the administration of ALA-PDT.
ALA-PDT can effectively reduce the DCS symptoms and the number of lymphocytes, macrophages, and neutrophils within the skin lesions.
头皮解剖性蜂窝织炎 (DCS) 对患者的身体健康和身体形象有重大影响。由于 DCS 对常规治疗反应不佳，因此需要寻找替代治疗策略。本研究旨在探讨 5-氨基酮戊酸光动力疗法 (ALA-PDT) 治疗 DCS 的疗效。
2022 年 6 月至 2023 年 6 月期间，我院对 12 例单纯接受 ALA-PDT 治疗的 DCS 男性患者进行了研究。其中 2 例患者在治疗前后进行了活检以进行比较。治疗 10 天后，通过评估病历记录的症状评分以及治疗前后的照片，评估治疗效果。此外，还提取了治疗对疼痛缓解和中位数复发率的影响。
在纳入的 12 例患者中，大多数患者（75%）的结节或脓肿明显减少。3 例患者（25%）疼痛缓解明显，7 例患者（58.3%）疼痛缓解中度。对于皮下窦道症状，3 例患者（27.3%）中度改善，7 例患者（63.6%）轻度改善。6 例患者（75%）脱发轻度改善。病理结果显示，ALA-PDT 给药后皮肤病变中的淋巴细胞、巨噬细胞和中性粒细胞数量减少。
ALA-PDT 可有效减轻 DCS 症状和皮肤病变中的淋巴细胞、巨噬细胞和中性粒细胞数量。
