Feng Yuxin, Zhang Yuhui, Guo Hongzuo, Lin Zheng, Chen Hongqiang, Wu Yan, Gao Xing-Hua, Chen Hong-Duo
Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
Department of General Surgery, Shandong Qianfoshan Hospital, Jinan, China.
Lasers Surg Med. 2019 Apr;51(4):332-338. doi: 10.1002/lsm.23016. Epub 2018 Aug 23.
Dissecting cellulitis of the scalp (DCS) is difficult to be treated and 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) is considered to be a potential treatment for inflammatory skin diseases.
To analyze the efficacy and safety of ALA-PDT on DCS.
The treatment areas of DCS patients were incubated with freshly prepared 10% ALA for 3 hours. The 633 ± 10 nm light with the intensity of 80-100 mw/cm was used as the irradiation source of ALA-PDT, and the irradiation time was 20-30 minutes. Three sessions were applied at an interval of 10-15 days. According to the reduction of lesions and the improvements of patients' symptoms after each session, the objective assessment of therapeutic effect was divided into four grades. The adverse effects were recorded.
Seven male DCS patients finished the treatments and assessments. One month after three sessions of treatment, one patient recovered, three patients received significant improvement, and one patients received medium improvement. At the 3-month follow-up, two patients recovered, four patients received significant improvement, and one patients received medium improvement. The patients tolerated well to the therapy without any severe adverse effects.
10% ALA-PDT is effective and safe on male DCS patients. As a localized and less invasive treatment, it provides a preferable choice for DCS patients. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.
头皮穿掘性蜂窝织炎（DCS）难以治疗，5-氨基酮戊酸光动力疗法（ALA-PDT）被认为是治疗炎症性皮肤病的一种潜在方法。
分析ALA-PDT治疗DCS的疗效和安全性。
DCS患者的治疗区域用新配制的10% ALA孵育3小时。使用波长633±10nm、强度80 - 100mw/cm²的光作为ALA-PDT的照射源，照射时间为20 - 30分钟。每隔10 - 15天进行3次治疗。根据每次治疗后皮损的减轻情况和患者症状的改善情况，将治疗效果的客观评估分为四个等级。记录不良反应。
7例男性DCS患者完成了治疗和评估。3次治疗1个月后，1例患者痊愈，3例患者显著改善，1例患者中度改善。在3个月的随访中，2例患者痊愈，4例患者显著改善，1例患者中度改善。患者对该治疗耐受性良好，未出现任何严重不良反应。
10% ALA-PDT对男性DCS患者有效且安全。作为一种局部且侵入性较小的治疗方法，它为DCS患者提供了一个较好的选择。激光外科与医学。©2018威利期刊公司。
