β-肾上腺素能受体阻断药物对脑血流量的影响。
The effect of beta-adrenergic receptor blocking drugs on cerebral blood flow.
作者信息
Griffith D N, James I M, Newbury P A, Woollard M L
出版信息
Br J Clin Pharmacol. 1979 May;7(5):491-4. doi: 10.1111/j.1365-2125.1979.tb00991.x.
Abstract
1 Cerebral blood flow (CBF) was measured by the 133xenon inhalation method in 33 newly-diagnosed hypertensive patients prior to commencing therapy. 2 Blood pressure was treated by using a varying sequence of four different drugs, namely labetalol, metoprolol, oxprenolol and sotalol, each of which is a beta-adrenergic receptor blocking agent, but with differing additional properties. 3 CBF measurements were repeated when blood pressure was controlled. No significant change in CBF was found with any of the four drugs, in contrast to the fall which has been reported when drugs of this type are administered acutely.
摘要
- 采用氙-133吸入法对33例新诊断的高血压患者在开始治疗前测量脑血流量（CBF）。2. 通过使用四种不同药物的不同顺序治疗血压，这四种药物分别是拉贝洛尔、美托洛尔、氧烯洛尔和索他洛尔，它们均为β-肾上腺素能受体阻滞剂，但具有不同的其他特性。3. 血压得到控制时重复测量CBF。结果发现，这四种药物中的任何一种都未使CBF发生显著变化，这与急性给予这类药物时所报道的血流量下降情况形成对比。
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