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β-肾上腺素能受体阻断药物对脑血流量的影响。

The effect of beta-adrenergic receptor blocking drugs on cerebral blood flow.

作者信息

Griffith D N, James I M, Newbury P A, Woollard M L

出版信息

Br J Clin Pharmacol. 1979 May;7(5):491-4. doi: 10.1111/j.1365-2125.1979.tb00991.x.

DOI:10.1111/j.1365-2125.1979.tb00991.x
PMID:38822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429570/
Abstract

1 Cerebral blood flow (CBF) was measured by the 133xenon inhalation method in 33 newly-diagnosed hypertensive patients prior to commencing therapy. 2 Blood pressure was treated by using a varying sequence of four different drugs, namely labetalol, metoprolol, oxprenolol and sotalol, each of which is a beta-adrenergic receptor blocking agent, but with differing additional properties. 3 CBF measurements were repeated when blood pressure was controlled. No significant change in CBF was found with any of the four drugs, in contrast to the fall which has been reported when drugs of this type are administered acutely.

摘要
  1. 采用氙-133吸入法对33例新诊断的高血压患者在开始治疗前测量脑血流量（CBF）。2. 通过使用四种不同药物的不同顺序治疗血压，这四种药物分别是拉贝洛尔、美托洛尔、氧烯洛尔和索他洛尔，它们均为β-肾上腺素能受体阻滞剂，但具有不同的其他特性。3. 血压得到控制时重复测量CBF。结果发现，这四种药物中的任何一种都未使CBF发生显著变化，这与急性给予这类药物时所报道的血流量下降情况形成对比。

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本文引用的文献

1
ELECTRON MICROSCOPIC OBSERVATIONS ON HUMAN INTRACRANIAL ARTERIES. II. INNERVATION.人类颅内动脉的电子显微镜观察。II. 神经支配
Arch Neurol. 1964 Feb;10:158-64. doi: 10.1001/archneur.1964.00460140044007.
2
The action of drugs on the cerebral circulation.药物对脑循环的作用。
Pharmacol Rev. 1959 Mar;11(1):1-85.
3
Mode of sympathetic innervation of the cerebral vessels demonstrated by the fluorescent histochemical technique in rats and cats.用荧光组织化学技术在大鼠和猫身上显示的脑血管交感神经支配模式。
Nihon Geka Hokan. 1969 Mar 1;38(2):227-35.
4
Ultrastructural changes in the nerves innervating the cerebral artery after sympathectomy.交感神经切除术后支配脑动脉的神经的超微结构变化。
Z Zellforsch Mikrosk Anat. 1970;109(4):465-80. doi: 10.1007/BF00343962.
5
Thoracic chemoreceptors in the dog. A histological and electrophysiological study of the location, innervation and blood supply of the aortic bodies.犬的胸段化学感受器。主动脉体位置、神经支配及血液供应的组织学与电生理学研究。
Circ Res. 1970 Feb;26(2):235-47. doi: 10.1161/01.res.26.2.235.
6
Regional hemodynamic effects of beta-adrenergic blockade with propranolol in the unanesthetized primate.普萘洛尔对未麻醉灵长类动物β-肾上腺素能阻滞的局部血流动力学效应
Am Heart J. 1973 Jan;85(1):97-102. doi: 10.1016/0002-8703(73)90531-0.
7
The role of the carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels.颈动脉体化学感受器和颈动脉窦压力感受器在脑血管控制中的作用。
J Physiol. 1974 Mar;237(2):315-40. doi: 10.1113/jphysiol.1974.sp010484.
8
The role of baroreceptors and chemoreceptors in the regulation of the cerebral circulation.
Clin Sci Mol Med. 1975 Nov;49(5):465-71. doi: 10.1042/cs0490465.
9
Factors affecting the cerebrovascular response to noradrenaline in the dog.影响犬脑血管对去甲肾上腺素反应的因素。
Br J Pharmacol. 1975 Jun;54(2):129-43.
10
The effect of acebutolol on the cerebral circulation of man.醋丁洛尔对人体脑循环的影响。
Br J Clin Pharmacol. 1977 Jun;4(3):373-5. doi: 10.1111/j.1365-2125.1977.tb00727.x.