Schmiegel W H, Kalthoff H, Arndt R, Gieseking J, Greten H, Klöppel G, Kreiker C, Ladak A, Lampe V, Ulrich S
Cancer Res. 1985 Mar;45(3):1402-7.
Three pancreatic cancer-associated antigens were characterized by use of monoclonal antibodies in immunobinding studies with various cellular and soluble target antigens, in immunoprecipitation, and in immunoperoxidase staining. C54-0 represents a tumor-associated Mr 122,000 antigen, which appears to be widely distributed on various epithelial tumors and to a lower extent on normal tissue. C1-N3 antigen exhibited a more restricted distribution, reacting with pancreatic and various gastrointestinal tract tumors as well as with chronically inflamed pancreatic tissue. The most specific antigen expression was observed for C1-P83 antigen, found on all exocrine tumors of the pancreas, but not on normal or chronically inflamed pancreatic tissue.
通过使用单克隆抗体，在与各种细胞和可溶性靶抗原的免疫结合研究、免疫沉淀以及免疫过氧化物酶染色中，对三种胰腺癌相关抗原进行了表征。C54-0代表一种肿瘤相关的分子量为122,000的抗原，它似乎广泛分布于各种上皮肿瘤，在正常组织中的分布程度较低。C1-N3抗原表现出更局限的分布，与胰腺和各种胃肠道肿瘤以及慢性炎症性胰腺组织发生反应。在胰腺的所有外分泌肿瘤中发现的C1-P83抗原表现出最特异的抗原表达，而在正常或慢性炎症性胰腺组织中未发现。
