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1
A monoclonal antibody with binding and inhibiting activity towards human pancreatic carcinoma cells. I. Immunohistological and immunochemical characterization of a murine monoclonal antibody selecting for well differentiated adenocarcinomas of the pancreas.一种对人胰腺癌细胞具有结合和抑制活性的单克隆抗体。I. 一种针对胰腺高分化腺癌筛选出的鼠单克隆抗体的免疫组织化学和免疫化学特征。
Cancer Immunol Immunother. 1986;23(3):185-91. doi: 10.1007/BF00205648.
2
Similarities in function between pancreatic tumor cells and macrophages and their inhibition by murine monoclonal antibodies.胰腺肿瘤细胞与巨噬细胞之间的功能相似性及其被鼠单克隆抗体抑制的情况。
Behring Inst Mitt. 1988 Apr(82):240-64.
3
Murine monoclonal IgG3 antibodies to human colorectal tumor-associated antigens: production and characterization of antibodies active in both antibody-dependent cellular cytotoxicity and complement-mediated cytolysis.抗人结肠直肠癌相关抗原的鼠单克隆IgG3抗体：在抗体依赖性细胞毒性和补体介导的细胞溶解中均具有活性的抗体的产生及特性分析
Cancer Res. 1989 May 15;49(10):2766-72.
4
Tissue distribution, immunochemical characterization, and biosynthesis of 47D10, a tumor-associated surface glycoprotein.肿瘤相关表面糖蛋白47D10的组织分布、免疫化学特性及生物合成
Cancer Res. 1987 Jan 1;47(1):241-50.
5
Human pancreatic cancer-associated antigens detected by murine monoclonal antibodies.用鼠单克隆抗体检测到的人胰腺癌相关抗原。
Cancer Res. 1985 Dec;45(12 Pt 1):6179-87.
6
Retargeting of human lymphocytes against human ovarian carcinoma cells by bispecific antibodies: from laboratory to clinic.双特异性抗体介导人淋巴细胞对人卵巢癌细胞的重新靶向作用：从实验室到临床
Int J Clin Lab Res. 1991;21(2):159-64. doi: 10.1007/BF02591636.
7
Radiolocalization of human small cell lung cancer and antigen-positive normal tissues using monoclonal antibody LS2D617.使用单克隆抗体LS2D617对人小细胞肺癌和抗原阳性正常组织进行放射性定位。
Cancer Res. 1990 May 15;50(10):3124-30.
8
Single-chain antibodies in pancreatic cancer.胰腺癌中的单链抗体。
Ann N Y Acad Sci. 1999 Jun 30;880:263-80. doi: 10.1111/j.1749-6632.1999.tb09531.x.
9
Modification of monoclonal antibody carbohydrates by oxidation, conjugation, or deoxymannojirimycin does not interfere with antibody effector functions.通过氧化、偶联或脱氧甘露基野尻霉素对单克隆抗体碳水化合物进行修饰不会干扰抗体的效应器功能。
Cancer Immunol Immunother. 1994 Jan;38(1):23-30. doi: 10.1007/BF01517166.
10
Production and characterization of monoclonal antibody to a 60-kD glycoprotein in ovarian carcinoma.卵巢癌中一种60-kD糖蛋白单克隆抗体的制备与鉴定
Hybridoma. 1985 Summer;4(2):153-62. doi: 10.1089/hyb.1985.4.153.

引用本文的文献

1
Pancreatic cancer: a review of emerging therapies.胰腺癌：新兴疗法综述
Drugs. 2000 May;59(5):1071-89. doi: 10.2165/00003495-200059050-00004.
2
Adjuvant therapy of pancreatic cancer using monoclonal antibodies and immune response modifiers.使用单克隆抗体和免疫反应调节剂对胰腺癌进行辅助治疗。
Int J Pancreatol. 1997 Feb;21(1):43-52. doi: 10.1007/BF02785919.
3
Intratumoral injection of an adriamycin immunoconjugate against human pancreatic cancer xenografts.针对人胰腺癌异种移植瘤进行阿霉素免疫偶联物的瘤内注射。
Jpn J Cancer Res. 1995 Nov;86(11):1072-9. doi: 10.1111/j.1349-7006.1995.tb03023.x.
4
In vivo labelling of granulocytes with 99mTc anti-NCA monoclonal antibodies for imaging inflammation.用99mTc抗NCA单克隆抗体对粒细胞进行体内标记以成像炎症。
Eur J Nucl Med. 1988;14(7-8):367-73. doi: 10.1007/BF00254386.
5
[Immunohistochemistry in pancreatic cancer with new monoclonal antibodies].[新型单克隆抗体在胰腺癌中的免疫组织化学研究]
Langenbecks Arch Chir. 1987;371(4):243-52. doi: 10.1007/BF01258972.
6
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.通过聚合酶链反应克隆免疫球蛋白可变区以进行表达。
Proc Natl Acad Sci U S A. 1989 May;86(10):3833-7. doi: 10.1073/pnas.86.10.3833.
7
Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas.支持循环血清癌胚抗原（CEA）与CEA表达癌的免疫闪烁显像无关的定量考量。
Eur J Nucl Med. 1988;14(11):523-8. doi: 10.1007/BF00286769.
8
Immunochemical and immunohistological analyses of tumor-associated antigens defined by murine monoclonal antibodies against human pancreatic carcinoma cells.针对人胰腺癌细胞的鼠单克隆抗体所定义的肿瘤相关抗原的免疫化学和免疫组织学分析。
Jpn J Cancer Res. 1988 Feb;79(2):264-74. doi: 10.1111/j.1349-7006.1988.tb01586.x.
9
Percolation and binding of monoclonal antibody BW494 to pancreatic carcinoma tissues during high dose immunotherapy and consequences for future therapy modalities.高剂量免疫治疗期间单克隆抗体BW494在胰腺癌组织中的渗透与结合及其对未来治疗方式的影响
Br J Cancer Suppl. 1990 Jul;10:37-9.
10
Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2.由新型鼠单克隆抗体Pak-1和Pak-2所定义的人胰腺腺癌相关抗原。
Gastroenterol Jpn. 1990 Apr;25(2):236-43. doi: 10.1007/BF02776822.

本文引用的文献

1
Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.唾液酸的定量测定。II. 比色间苯二酚 - 盐酸法。
Biochim Biophys Acta. 1957 Jun;24(3):604-11. doi: 10.1016/0006-3002(57)90254-8.
2
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
3
A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma.单唾液酸神经节苷脂是一种结肠癌的单克隆抗体定义抗原。
Science. 1981 Apr 3;212(4490):55-6. doi: 10.1126/science.7209516.
4
A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.一种与胃肠道癌相关的单克隆抗体定义抗原是一种含有唾液酸化乳糖-N-岩藻五糖II的神经节苷脂。
J Biol Chem. 1982 Dec 10;257(23):14365-9.
5
GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody.GD3，一种人类黑色素瘤中显著的神经节苷脂。用小鼠单克隆抗体进行检测与表征。
J Exp Med. 1982 Apr 1;155(4):1133-47. doi: 10.1084/jem.155.4.1133.
6
Gangliosides: structure, isolation, and analysis.神经节苷脂：结构、分离与分析
Methods Enzymol. 1982;83:139-91. doi: 10.1016/0076-6879(82)83012-7.
7
The effect of pre-injection of mice with pristane on ascites tumour formation and monoclonal antibody production.预先给小鼠注射降植烷对腹水肿瘤形成和单克隆抗体产生的影响。
J Immunol Methods. 1983 Jul 29;61(3):317-20. doi: 10.1016/0022-1759(83)90225-9.
8
Gastrointestinal cancer-associated antigen in immunoperoxidase assay.免疫过氧化物酶测定中的胃肠道癌相关抗原
Cancer Res. 1982 Nov;42(11):4820-3.
9
Quantitative evaluation of the localization of a monoclonal antibody (791T/36) in human osteogenic sarcoma xenografts.单克隆抗体（791T/36）在人骨肉瘤异种移植瘤中定位的定量评估。
Eur J Cancer Clin Oncol. 1984 Apr;20(4):515-24. doi: 10.1016/0277-5379(84)90238-4.
10
Monoclonal antibody-directed effector cells selectively lyse human melanoma cells in vitro and in vivo.单克隆抗体导向的效应细胞在体外和体内均可选择性地裂解人黑色素瘤细胞。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5407-11. doi: 10.1073/pnas.80.17.5407.

一种对人胰腺癌细胞具有结合和抑制活性的单克隆抗体。I. 一种针对胰腺高分化腺癌筛选出的鼠单克隆抗体的免疫组织化学和免疫化学特征。

A monoclonal antibody with binding and inhibiting activity towards human pancreatic carcinoma cells. I. Immunohistological and immunochemical characterization of a murine monoclonal antibody selecting for well differentiated adenocarcinomas of the pancreas.

作者信息

Bosslet K, Kern H F, Kanzy E J, Steinstraesser A, Schwarz A, Lüben G, Schorlemmer H U, Sedlacek H H

出版信息

Cancer Immunol Immunother. 1986;23(3):185-91. doi: 10.1007/BF00205648.

DOI:10.1007/BF00205648
PMID:3539336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038228/
Abstract

The murine monoclonal antibody (MAb) BW 494 was characterized in relation to its tissue specificity, the epitope recognized, in vitro and in vivo radiolocalization and its potential to mediate antibody dependent cellular cytotoxicity (ADCC) and complement mediated cytolysis (CMC). The MAb defined carbohydrate epitope located on a greater than 200 k daltons glycoprotein was mainly expressed on the majority of well differentiated adenocarcinomas of the pancreas. Furthermore, the epitope is accessible to MAb BW 494 in vivo, allowing an enrichment of radioactive antibody at the tumor site in nude mice. Additionally, MAb BW 494 is able to use human peripheral blood lymphocytes as effector cells for ADCC reactions against appropriate tumor target cells in vitro. In contrast, the antibody does not mediate human or rabbit CMC.

摘要

对鼠单克隆抗体（MAb）BW 494进行了特性研究，涉及组织特异性、所识别的表位、体内外放射性定位以及介导抗体依赖性细胞毒性（ADCC）和补体介导的细胞溶解（CMC）的潜力。该单克隆抗体所定义的位于大于200千道尔顿糖蛋白上的碳水化合物表位主要表达于大多数高分化胰腺腺癌。此外，该表位在体内可被单克隆抗体BW 494识别，使得放射性抗体在裸鼠肿瘤部位富集。另外，单克隆抗体BW 494能够利用人外周血淋巴细胞作为效应细胞，在体外针对合适的肿瘤靶细胞进行ADCC反应。相比之下，该抗体不介导人或兔的CMC。