Ufa Eye Research Institute, Ufa, Russia.
Ufa Eye Institute, Ufa, Russia.
Acta Ophthalmol. 2024 Nov;102(7):e1057-e1065. doi: 10.1111/aos.16726. Epub 2024 Jun 1.
To assess associations between atrial fibrillation/atrial flutter (AF) and ocular parameters and diseases.
The population-based Ural Eye and Medical Study (UEMS) and the Ural Very Old Study (UVOS) included 4894 individuals (age: 40+ years) and 835 individuals (age: 85+ years), respectively.
In the UEMS, AF prevalence (80/4894; 1.6%; 95% CI: 1.3, 2.0) increased from 1/1029 (0.1%) in the age group of 40 to <50 years to 29/619 (4.7%) and 12/159 (7.5%) in the age groups of 70 to <80 years and 80+ years, respectively. Higher AF prevalence correlated with older age (OR: 1.08; 95% CI: 1.04, 1.12; p < 0.001), urban region of habitation (OR: 1.08; 95% CI: 1.04, 1.12; p < 0.001), higher prevalence of cardiovascular disease/stroke (OR: 2.50; 95% CI: 1.32, 4.72; p < 0.001) and lower prevalence of neck pain (OR: 0.35; 95% CI: 0.14, 0.85; p = 0.02), higher serum concentration of bilirubin (OR: 1.03; 95% CI: 1.02, 1.05; p < 0.001) and lower prothrombin index (OR: 0.96; 95% CI: 0.93, 0.99; p = 0.003), higher stage of arterial hypertension (OR: 1.52; 95% CI: 1.01, 2.28; p = 0.04) and higher ankle-brachial index (OR: 22.1; 95% CI: 4.45, 1.10; p < 0.001). In that model, AF prevalence was not associated with ocular parameters such as intraocular pressure (p = 0.52), retinal nerve fibre layer thickness (p = 0.70), refractive error (p = 0.13), axial length (p = 0.14), nuclear cataract degree (p = 0.50) and prevalence (p = 0.40), cortical cataract degree (p = 0.43) and presence (p = 0.17), lens pseudoexfoliation (p = 0.58), status after cataract surgery (p = 0.38), age-related macular degeneration prevalence (p = 0.63), open-angle glaucoma presence (p = 0.90) and stage (p = 0.55), angle-closure glaucoma prevalence (p = 0.99) and stage (p = 0.99), diabetic retinopathy prevalence presence (p = 0.37) and stage (p = 0.32), and myopic macular degeneration (p = 0.98). In the UVOS, similar results were obtained.
In these multi-ethnic populations from Russia, AF prevalence was not associated with any major ocular disease and may not play a major role in the pathogenesis of these disorders.
评估心房颤动/心房扑动（AF）与眼部参数和疾病的关联。
基于人群的乌拉尔眼与医学研究（Ural Eye and Medical Study，UEMS）和乌拉尔高龄研究（Ural Very Old Study，UVOS）纳入了 4894 名（年龄：40 岁以上）和 835 名（年龄：85 岁以上）个体。
在 UEMS 中，AF 患病率（80/4894；1.6%；95%CI：1.3，2.0）从 40 岁以下年龄组的 1/1029（0.1%）上升至 70 岁以下年龄组的 29/619（4.7%）和 80 岁以上年龄组的 12/159（7.5%）。较高的 AF 患病率与年龄较大（OR：1.08；95%CI：1.04，1.12；p<0.001）、居住地区为城市（OR：1.08；95%CI：1.04，1.12；p<0.001）、心血管疾病/中风的患病率较高（OR：2.50；95%CI：1.32，4.72；p<0.001）和颈部疼痛的患病率较低（OR：0.35；95%CI：0.14，0.85；p=0.02）、血清胆红素浓度较高（OR：1.03；95%CI：1.02，1.05；p<0.001）和凝血酶原指数较低（OR：0.96；95%CI：0.93，0.99；p=0.003）、高血压分期较高（OR：1.52；95%CI：1.01，2.28；p=0.04）和踝臂指数较高（OR：22.1；95%CI：4.45，1.10；p<0.001）相关。在该模型中，AF 患病率与眼压（p=0.52）、视网膜神经纤维层厚度（p=0.70）、屈光不正（p=0.13）、眼轴长度（p=0.14）、核性白内障程度（p=0.50）和患病率（p=0.40）、皮质性白内障程度（p=0.43）和存在（p=0.17）、晶状体假性剥脱（p=0.58）、白内障手术后状态（p=0.38）、年龄相关性黄斑变性患病率（p=0.63）、开角型青光眼存在（p=0.90）和分期（p=0.55）、闭角型青光眼患病率（p=0.99）和分期（p=0.99）、糖尿病性视网膜病变患病率存在（p=0.37）和分期（p=0.32）、近视性黄斑变性（p=0.98）等眼部主要疾病无关。
在这些来自俄罗斯的多民族人群中，AF 患病率与任何主要眼部疾病均无关，并且可能在这些疾病的发病机制中不起主要作用。
