Bikbov Mukharram M, Kazakbaeva Gyulli M, Gilmanshin Timur R, Zainullin Rinat M, Iakupova Ellina M, Fakhretdinova Albina A, Tuliakova Azaliia M, Rusakova Iuliia A, Panda-Jonas Songhomitra, Nuriev Ildar F, Zaynetdinov Artur F, Zinnatullin Ainur A, Arslangareeva Inga I, Gizzatov Ainur V, Bolshakova Natalia I, Safiullina Kamilia R, Jonas Jost B
Ufa Eye Research Institute, Ufa, Bashkortostan, Russia.
Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany.
Metabol Open. 2022 Apr 7;14:100183. doi: 10.1016/j.metop.2022.100183. eCollection 2022 Jun.
To examine prevalence and associated factors of the metabolic syndrome (MS) in populations in Russia.
Two population-based studies (Ural Eye and Medical Study (UEMS), Ural Very Old Study (UVOS)) were conducted in rural and urban regions in Bashkortostan/Russia and included participants aged 40+ years and 85+ years, respectively.
Out of 5895 UEMS participants, 1572 individuals had MS (prevalence:26.7%; 95% confidence interval (CI):25.5,27.8). The criteria of waist circumference, blood pressure, hyperglycemia, serum high-density lipoprotein concentration and serum triglyceride concentration were fulfilled by 4269 (72.4%; 95%CI:71.3,73.6), 3168 (53.7%; 95%CI:52.5,55.1), 1375 (23.3%; 95%CI:22.4,24.6), 712 (13.3%; 95%CI:12.4,14.2), and 1527 (28.6%; 95%CI:27.4,29.8) individuals, respectively. Higher MS prevalence was associated with older age (odds ratio (OR):1.03; 95%CI:1.02,1.04; < 0.001), female sex (OR:1.93; 95%CI:1.51,2.47; < 0.001), higher body height (OR:1.03; 95%CI:1.01,1.04; < 0.001), Russian ethnicity (OR:1.38; 95%CI:1.13,1.70; = 0.002), lower ankle-brachial index (OR:0.19; 95%CI:0.11,0.30; < 0.001), higher prevalence of lower backache (OR:1.29; 95%CI:1.08,1.52; = 0.004), cardiovascular disease (OR:2.32; 95%CI:1.92,2.78; < 0.001) and thyroid disease (OR:1.41; 95%CI:1.04,1.92; = 0.03), lower international normalized ratio (OR:0.55; 95%CI:0.32,0.95; = 0.03), lower prevalence of current smoking (OR:0.67; 95%CI:0.50,0.89; = 0.006), and higher prevalence of alcohol consumption (OR:1.35; 95%CI:1.11,1.64; = 0.003). Out of 1124 UVOS participants (age:88.2 ± 2.7 years; range:85-100 years), MS was present in 485 individuals (prevalence:43.1%; 95%CI:40.3,46.1). The criteria of waist circumference, blood pressure, hyperglycemia, serum high-density lipoprotein concentration and serum triglyceride concentration were fulfilled by 853 (75.9%; 95%CI:73.4,78.4), 1057 (94.0%; 95%CI:92.7,95.4), 320 (26.9%; 95%CI:24.3,29.5), 525 (46.7%; 95%CI:43.8,49.6), and 337 (30.0%; 95%CI:27.3,32.7, individuals, respectively. Higher MS prevalence was associated with female sex (OR:2.30; 95%CI:1.72,3.09; < 0.001) and higher serum concentration of aspartate transaminase (OR:1.02; 95%CI:1.01,1.03; = 0.007).
MS is common in Russia, increases with age up to about 70 years and then plateaus, is more common in women, and differs in its associated factors between middle-aged and very old populations.
研究俄罗斯人群中代谢综合征（MS）的患病率及相关因素。
在俄罗斯巴什基尔斯坦的农村和城市地区开展了两项基于人群的研究（乌拉尔眼与医学研究（UEMS）、乌拉尔高龄研究（UVOS）），分别纳入了40岁及以上和85岁及以上的参与者。
在5895名UEMS参与者中，1572人患有MS（患病率：26.7%；95%置信区间（CI）：25.5，27.8）。腰围、血压、高血糖、血清高密度脂蛋白浓度和血清甘油三酯浓度标准分别有4269人（72.4%；95%CI：71.3，73.6）、3168人（53.7%；95%CI：52.5，55.1）、1375人（23.3%；95%CI：22.4，24.6）、712人（13.3%；95%CI：12.4，14.2）和1527人（28.6%；95%CI：27.4，29.8）符合。较高的MS患病率与年龄较大（优势比（OR）：1.03；95%CI：1.02，1.04；<0.001）、女性（OR：1.93；95%CI：1.51，2.47；<0.001）、身高较高（OR：1.03；95%CI：1.01，1.04；<0.001）、俄罗斯族裔（OR：1.38；95%CI：1.13，1.70；=0.002）、较低的踝臂指数（OR：0.19；95%CI：0.11，0.30；<0.001）、较高的下背痛患病率（OR：1.29；95%CI：1.08，1.52；=0.004）、心血管疾病（OR：2.32；95%CI：1.92，2.78；<0.001）和甲状腺疾病（OR：1.41；95%CI：1.04，1.92；=0.03）、较低的国际标准化比值（OR：0.55；95%CI：0.32，0.95；=0.03）、较低的当前吸烟率（OR：0.67；95%CI：0.50，0.89；=0.006）以及较高的饮酒率（OR：1.35；95%CI：1.11，1.64；=0.003）相关。在1124名UVOS参与者（年龄：88.2±2.7岁；范围：85 - 100岁）中，485人患有MS（患病率：43.1%；95%CI：40.3，46.1）。腰围、血压、高血糖、血清高密度脂蛋白浓度和血清甘油三酯浓度标准分别有853人（75.9%；95%CI：73.4，78.4）、1057人（94.0%；95%CI：92.7，95.4）、320人（26.9%；95%CI：24.3，29.5）、525人（46.7%；95%CI：43.8，49.6）和337人（30.0%；95%CI：27.3，32.7）符合。较高的MS患病率与女性（OR：2.30；95%CI：1.72，3.09；<0.001）和较高的血清天冬氨酸转氨酶浓度（OR：1.02；95%CI：1.01，1.03；=0.007）相关。
MS在俄罗斯很常见，在70岁左右之前随年龄增加而上升，之后趋于平稳，在女性中更常见，且中年和高龄人群的相关因素有所不同。
