羟胺的生物活性：综述

Biologic activity of hydroxylamine: a review.

作者信息

Gross P

出版信息

Crit Rev Toxicol. 1985;14(1):87-99. doi: 10.3109/10408448509023765.

Abstract

Although hydroxylamine, as such, is a product of normal cellular metabolism it is also a potent mutagen in vitro. However, in spite of this potential, it has not been shown to possess carcinogenic capabilities. Indeed, this chemical has demonstrated carcinostatic activity against certain tumors in animals. In addition, hydroxylamine has been shown to inactivate or inhibit a number of cellular enzymes and some viruses in vitro. It is also a skin irritant and sensitizer. It causes dermatitis and it is corrosive to the eyes. Acute and chronic exposures to hydroxylamine have caused methemoglobinemia and sulfhemoglobinemia.

摘要

虽然羟胺本身是正常细胞代谢的产物，但它在体外也是一种强效诱变剂。然而，尽管有这种潜在危害，但尚未证明它具有致癌能力。实际上，这种化学物质已在动物实验中显示出对某些肿瘤的抗癌活性。此外，羟胺已被证明在体外能使多种细胞酶失活或受到抑制，还能抑制一些病毒。它也是一种皮肤刺激剂和致敏剂，会引起皮炎，对眼睛有腐蚀性。急性和慢性接触羟胺会导致高铁血红蛋白血症和硫血红蛋白血症。