School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, PR China.
Department of Gastroenterology, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Shanghai 200433, PR China.
Carbohydr Polym. 2024 Sep 1;339:122262. doi: 10.1016/j.carbpol.2024.122262. Epub 2024 May 13.
Chitosan has been widely used in biomedical fields due to its good antibacterial properties, excellent biocompatibility, and biodegradability. In this study, a pH-responsive and self-healing hydrogel was synthesized from 3-carboxyphenylboronic acid grafted with chitosan (CS-BA) and polyvinyl alcohol (PVA). The dynamic boronic ester bonds and intermolecular hydrogen bonds are responsible for the hydrogel formation. By changing the mass ratio of CS-BA and PVA, the tensile stress and compressive stress of hydrogel can controlled in the range of 0.61 kPa - 0.74 kPa and 295.28 kPa - 1108.1 kPa, respectively. After doping with tannic acid (TA)/iron nanocomplex (TAFe), the hydrogel successful killed tumor cells through the near infrared laser-induced photothermal conversion and the TAFe-triggered reactive oxygen species generation. Moreover, the photothermal conversion of the hydrogel and the antibacterial effect of CS and TA give the hydrogel a good antibacterial effect. The CS-BA/PVA/TAFe hydrogel exhibit good in vivo and in vitro anti-tumor recurrence and antibacterial ability, and therefore has the potential to be used as a powerful tool for the prevention of local tumor recurrence and bacterial infection after surgery.
壳聚糖由于其良好的抗菌性能、优异的生物相容性和可生物降解性，已广泛应用于生物医学领域。在这项研究中，通过 3-羧基苯硼酸接枝壳聚糖（CS-BA）和聚乙烯醇（PVA）合成了一种 pH 响应型自修复水凝胶。动态硼酸酯键和分子间氢键负责水凝胶的形成。通过改变 CS-BA 和 PVA 的质量比，可以将水凝胶的拉伸应力和压缩应力分别控制在 0.61 kPa-0.74 kPa 和 295.28 kPa-1108.1 kPa 的范围内。掺杂单宁酸（TA）/铁纳米复合物（TAFe）后，水凝胶通过近红外激光诱导的光热转换和 TAFe 触发的活性氧生成成功杀死肿瘤细胞。此外，水凝胶的光热转换和 CS 和 TA 的抗菌作用赋予水凝胶良好的抗菌效果。CS-BA/PVA/TAFe 水凝胶具有良好的体内和体外抗肿瘤复发和抗菌能力，因此有望成为预防手术后局部肿瘤复发和细菌感染的有力工具。
