Department of Clinical Sciences, Neurosciences, Umeå University, S-901 85 Umeå, Sweden.
Department of Radiation Sciences, Oncology, Umeå University, S-901 87 Umeå, Sweden.
Am J Epidemiol. 2024 Nov 4;193(11):1592-1599. doi: 10.1093/aje/kwae100.
Whether use of antidepressants is related to the risk of developing lower-grade (WHO grades 2-3) and higher-grade (WHO grade 4) glioma was investigated in this study. A registry-based case-control study was performed with 1283 glioma case patients and 6400 age-, sex-, and geographically matched control participants who were diagnosed in Sweden during 2009-2013. Conditional logistic regression was used to analyze whether selective serotonin reuptake inhibitors (SSRIs) or non-SSRIs were associated with the risk of developing lower- or higher-grade glioma in the study population. Our results show that use of antidepressant medication was not associated with the risk of developing glioma. We also performed a meta-analysis in which the data set from the present study was combined with results from 2 previous epidemiologic studies to answer the same questions. The meta-analysis showed a modest risk reduction of developing glioma in relation to antidepressant treatment (odds ratio = 0.90; 95% CI, 0.83-0.97) when all glioma subgroups and all forms of antidepressant medications were combined. In conclusion, it remains possible that antidepressants may have common monoaminergic mechanism(s) that reduce the risk of developing glioma.
本研究旨在探讨使用抗抑郁药是否与低级别（世界卫生组织分级 2-3 级）和高级别（世界卫生组织分级 4 级）胶质瘤的发病风险相关。本研究采用基于登记的病例对照研究，纳入了 2009-2013 年在瑞典诊断的 1283 例胶质瘤病例患者和 6400 名年龄、性别和地理位置匹配的对照参与者。采用条件逻辑回归分析了选择性 5-羟色胺再摄取抑制剂（SSRIs）或非 SSRIs 是否与研究人群中低级别或高级别胶质瘤的发病风险相关。我们的研究结果表明，使用抗抑郁药物与胶质瘤的发病风险无关。我们还进行了一项荟萃分析，将本研究的数据与之前两项流行病学研究的结果相结合，以回答相同的问题。荟萃分析结果显示，与未接受抗抑郁治疗相比，接受抗抑郁治疗与胶质瘤发病风险适度降低相关（比值比=0.90；95%CI，0.83-0.97），当所有胶质瘤亚组和所有类型的抗抑郁药物联合使用时。综上所述，抗抑郁药可能具有共同的单胺能机制，从而降低患胶质瘤的风险。
