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肠道微生物组在高血压管理中的未开发潜力。

Untapped potential of gut microbiome for hypertension management.

机构信息

Department of Pharmacy, The First Hospital of China Medical University, Shenyang, Liaoning, China.

School of Pharmacy, Institute of Materia Medica, North Sichuan Medical College, Nanchang, Sichuan, China.

出版信息

Gut Microbes. 2024 Jan-Dec;16(1):2356278. doi: 10.1080/19490976.2024.2356278. Epub 2024 Jun 2.

Abstract

The gut microbiota has been shown to be associated with a range of illnesses and disorders, including hypertension, which is recognized as the primary factor contributing to the development of serious cardiovascular diseases. In this review, we conducted a comprehensive analysis of the progression of the research domain pertaining to gut microbiota and hypertension. Our primary emphasis was on the interplay between gut microbiota and blood pressure that are mediated by host and gut microbiota-derived metabolites. Additionally, we elaborate the reciprocal communication between gut microbiota and antihypertensive drugs, and its influence on the blood pressure of the host. The field of computer science has seen rapid progress with its great potential in the application in biomedical sciences, we prompt an exploration of the use of microbiome databases and artificial intelligence in the realm of high blood pressure prediction and prevention. We propose the use of gut microbiota as potential biomarkers in the context of hypertension prevention and therapy.

摘要

肠道微生物群已被证明与多种疾病和障碍有关,包括高血压,高血压被认为是导致严重心血管疾病的主要因素。在这篇综述中,我们对肠道微生物群与高血压研究领域的进展进行了全面分析。我们主要关注的是肠道微生物群与血压之间的相互作用,这些作用是由宿主和肠道微生物群衍生的代谢物介导的。此外,我们还阐述了肠道微生物群与抗高血压药物之间的相互交流,以及它对宿主血压的影响。计算机科学领域取得了快速进展,在生物医学科学中的应用潜力巨大,我们呼吁探索使用微生物组数据库和人工智能来进行高血压预测和预防。我们提出将肠道微生物群作为高血压预防和治疗中潜在的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/877a/11152106/af3c71e1e013/KGMI_A_2356278_F0001_OC.jpg

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