Mruk-Mazurkiewicz Honorata, Kulaszyńska Monika, Jakubczyk Karolina, Janda-Milczarek Katarzyna, Czarnecka Wiktoria, Rębacz-Maron Ewa, Zacha Sławomir, Sieńko Jerzy, Zeair Samir, Dalewski Bartosz, Marlicz Wojciech, Łoniewski Igor, Skonieczna-Żydecka Karolina
Department of Biochemical Science, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Biomedicines. 2023 Mar 20;11(3):952. doi: 10.3390/biomedicines11030952.
As pharmacology and science progress, we discover new generations of medicines. This relationship is a response to the increasing demand for medicaments and is powered by progress in medicine and research about the respective entities. However, we have questions about the efficiency of pharmacotherapy in individual groups of patients. The effectiveness of therapy is controlled by many variables, such as genetic predisposition, age, sex and diet. Therefore, we must also pay attention to the microbiota, which fulfill a lot of functions in the human body. Drugs used in psychiatry, gastroenterology, diabetology and other fields of medicine have been demonstrated to possess much potential to change the composition and probably the function of the intestinal microbiota, which consequently creates long-term risks of developing chronic diseases. The article describes the amazing interactions between gut microbes and drugs currently used in healthcare.
随着药理学和科学的进步，我们发现了新一代药物。这种关系是对药物需求不断增加的一种回应，其动力来自医学的进步以及对相关实体的研究。然而，我们对个别患者群体中药物治疗的效果存在疑问。治疗效果受许多变量控制，如遗传易感性、年龄、性别和饮食。因此，我们也必须关注微生物群，它们在人体中发挥着许多功能。精神病学、胃肠病学、糖尿病学和其他医学领域使用的药物已被证明有很大潜力改变肠道微生物群的组成，可能还会改变其功能，从而产生患慢性病的长期风险。本文描述了肠道微生物与目前医疗保健中使用的药物之间惊人的相互作用。
