Department of Nutrition and Dietetics, University of Winchester, Winchester, UK.
Department of Medicine, KU Leuven, Leuven, Belgium.
Pediatr Allergy Immunol. 2024 Jun;35(6):e14163. doi: 10.1111/pai.14163.
The recognition of constipation as a possible non-Immunoglobulin E (IgE)-mediated allergic condition is challenging because functional constipation (unrelated to food allergies) is a common health problem with a reported worldwide prevalence rate of up to 32.2% in children. However, many studies in children report challenge proven cow's milk allergy and constipation as a primary symptom and have found that between 28% and 78% of children improve on a cow's milk elimination diet. Due to the paucity of data and a focus on IgE-mediated allergy, not all food allergy guidelines list constipation as a symptom of food allergy. Yet, it is included in all cow's milk allergy guidelines available in English language. The Exploring Non-IgE-Mediated Allergy (ENIGMA) Task Force (TF) of the European Academy for Allergy and Clinical Immunology (EAACI) considers in this paper constipation in the context of failure of standard treatment and discuss the role of food allergens as culprit in constipation in children. This position paper used the Delphi approach in reaching consensus on both diagnosis and management, as currently published data are insufficient to support a systematic review.
认识到便秘可能是一种非免疫球蛋白 E（IgE）介导的过敏状态具有挑战性，因为功能性便秘（与食物过敏无关）是一种常见的健康问题，据报道全球儿童的患病率高达 32.2%。然而，许多儿童研究报告了已证实的牛奶过敏和便秘作为主要症状，并发现 28%至 78%的儿童在进行牛奶消除饮食后有所改善。由于数据的缺乏和对 IgE 介导的过敏的关注，并非所有食物过敏指南都将便秘列为食物过敏的症状。然而，它包含在所有可用的英语牛奶过敏指南中。欧洲过敏与临床免疫学学会（EAACI）探索非 IgE 介导过敏（ENIGMA）工作组（TF）在本文中考虑了在标准治疗失败的情况下便秘，并讨论了食物过敏原作为儿童便秘罪魁祸首的作用。本立场文件采用德尔菲法就诊断和管理达成共识，因为目前发表的数据不足以支持系统评价。
