Translational Research Laboratory, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.
Sociedade Pernambucana de Combate ao Cancer, Hospital de Câncer de Pernambuco (HCP), Recife, Brazil.
J Surg Oncol. 2024 Sep;130(4):669-680. doi: 10.1002/jso.27716. Epub 2024 Jun 2.
Breast cancer (BC) is associated with a continuous increase in incidence, with high mortality rates in several countries. CD44, STAT3, and SOX2 are related to regulating of somatic cell division, tumorigenesis, and metastasis in BC.
A cross-sectional study was carried out at the Hospital de Cancer de Pernambuco (HCP) between 2017 and 2018. Fifty-one women with locally advanced (LA) and 14 with metastatic BC were included in the study.
High CD44+/CD24 and CD44+/CD24/SOX2+ levels in Luminal B (LB), HER2+, and triple-negative breast cancer (TNBC) compared with controls (p < 0.05). Low CD44+/CD24STAT3+ levels in LB, HER2+, and TNBC compared with controls (p < 0.05). High T lymphocytes, and low STAT3 + T, and SOX2 + T levels in BC patients (p < 0.05). High SOX2 + T levels in patients with axillary lymph node-negative (N0) compared with the axillary lymph node-positives (N1 and N2 groups; p < 0.05). High SOX2 + T levels in N1 compared to N2 (p < 0.05). High T lymphocytes and low SOX2 + T levels in the LA tumor compared to metastatic disease (p = 0.0007 and p = 0.02, respectively). High CD44 + /CD24STAT3+, and T lymphocyte levels in TNBC patients with LA tumor compared to metastatic (p < 0.05). Low STAT3 + T levels in TBNC patients with LA tumor compared to metastatic (p = 0.0266).
SOX2 and STAT3 expression on circulating T lymphocytes and CD44 + /CD24 cells in peripheral blood have prognostic roles in breast cancer. SOX2 and STAT3 expression are potential predictive biomarkers of disease progression in breast cancer regardless of tumor subtype.
乳腺癌（BC）的发病率持续上升，在多个国家死亡率较高。CD44、STAT3 和 SOX2 与调节体细胞分裂、肿瘤发生和转移有关。
本研究于 2017 年至 2018 年在 Pernambuco 癌症医院（HCP）进行了一项横断面研究。共纳入 51 例局部晚期（LA）和 14 例转移性 BC 女性患者。
与对照组相比，Luminal B（LB）、HER2+和三阴性乳腺癌（TNBC）中 CD44+/CD24 和 CD44+/CD24/SOX2+水平较高（p<0.05）。与对照组相比，LB、HER2+和 TNBC 中 CD44+/CD24STAT3+水平较低（p<0.05）。BC 患者中 T 淋巴细胞较高，而 STAT3+T 和 SOX2+T 水平较低（p<0.05）。与腋窝淋巴结阴性（N0）患者相比，腋窝淋巴结阳性（N1 和 N2 组）患者的 SOX2+T 水平较高（p<0.05）。与 N2 相比，N1 患者的 SOX2+T 水平较高（p<0.05）。与转移性疾病相比，LA 肿瘤中的 T 淋巴细胞较高，SOX2+T 水平较低（p=0.0007 和 p=0.02）。与转移性疾病相比，LA 肿瘤的 TNBC 患者中 CD44+/CD24STAT3+和 T 淋巴细胞水平较高（p<0.05）。与转移性疾病相比，LA 肿瘤的 TNBC 患者中 STAT3+T 水平较低（p=0.0266）。
循环 T 淋巴细胞和外周血 CD44+/CD24 细胞中 SOX2 和 STAT3 的表达在乳腺癌中具有预后作用。SOX2 和 STAT3 的表达是乳腺癌疾病进展的潜在预测生物标志物，与肿瘤亚型无关。
