Kwon Seong Soon, Yoon Seug Yun, Kim Kyoung-Ha, Park Byoung-Won, Lee Min-Ho, Kim Hyoungnae, Bang Duk Won
Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
J Lipid Atheroscler. 2024 May;13(2):184-193. doi: 10.12997/jla.2024.13.2.184. Epub 2024 Feb 22.
Serum hemoglobin (Hb) level affects the viscosity of blood. Several studies have reported that Hb level is associated with adverse cardiovascular outcome. However, there is a paucity of evidence on the association between serum Hb level and the risk of subclinical atherosclerosis. Thus, the objective of this study was to investigate the relationship between Hb level and risk of carotid plaque in a health checkup cohort.
This retrospective study analyzed a total of 3,805 individuals without history of cardiovascular disease (CVD) who underwent carotid ultrasonography (USG) between January 2016 and June 2018. Participants were divided into 4 groups based on Hb quartiles in each of male and female. Carotid plaque score was calculated based on USG reports. Multivariable logistic regression analysis was performed for each index of quartile groups regarding the risk of carotid plaque.
Of 3,805 individuals (mean age, 52.62±10.25 years; 2,674 [70.28%] males), mean Hb level was 15.11±0.75 g/dL in male and 13.35±0.74 g/dL in female. When the Q1 group was compared to the Q4, increasing quartile of Hb was associated with the presence of significant carotid plaque (plaque score ≥3) in male (adjusted odds ratio [OR], 1.538; 95% confidence interval [CI], 1.182-2.001; =0.001) and female (adjusted OR, 1.749; 95% CI, 1.058-2.676; =0.01).
A high Hb level is associated with an increased risk of carotid plaques in individuals without history of CVD. This finding may support the need for early screening of CVD in individuals with high Hb levels.
血清血红蛋白（Hb）水平会影响血液粘度。多项研究报告称，Hb水平与不良心血管结局相关。然而，关于血清Hb水平与亚临床动脉粥样硬化风险之间的关联，证据却很少。因此，本研究的目的是调查健康体检队列中Hb水平与颈动脉斑块风险之间的关系。
这项回顾性研究分析了2016年1月至2018年6月期间接受颈动脉超声检查（USG）的3805名无心血管疾病（CVD）病史的个体。参与者根据男性和女性各自的Hb四分位数分为4组。根据USG报告计算颈动脉斑块评分。对四分位数组的每个指标进行多变量逻辑回归分析，以评估颈动脉斑块风险。
在3805名个体中（平均年龄52.62±10.25岁；男性2674名[70.28%]），男性的平均Hb水平为15.11±0.75 g/dL，女性为13.35±0.74 g/dL。当将Q1组与Q4组进行比较时，男性（校正比值比[OR]，1.538；95%置信区间[CI]，1.182 - 2.001；P = 0.001）和女性（校正OR，1.749；95% CI，1.058 - 2.676；P = 0.01）中，Hb四分位数的增加与显著颈动脉斑块（斑块评分≥3）的存在相关。
在无CVD病史的个体中，高Hb水平与颈动脉斑块风险增加相关。这一发现可能支持对高Hb水平个体进行CVD早期筛查的必要性。
