Institute of Preventive Veterinary Sciences and Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, 310058, China.
Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Hangzhou, 310058, China.
Sci Data. 2024 Oct 7;11(1):1094. doi: 10.1038/s41597-024-03908-7.
Salmonella enterica serovar Gallinarum (S. Gallinarum) is an avian-specific pathogen responsible for fowl typhoid, a severe systemic disease with high mortality in chickens. This disease poses a substantial burden to the poultry industry, particularly in developing countries like China. However, comprehensive genome datasets on S. Gallinarum are lacking. Here, we present the most extensive S. Gallinarum genome dataset, comprising 574 well-collated samples. This dataset consists of 366 genomes sequenced in our laboratory and 208 publicly available genomes, collected from various continents over the past century. Using in silico prediction, we categorized S. Gallinarum into three distinct biovars. Regarding antimicrobial resistance, 238 strains (41.5%) carried antimicrobial resistance genes (ARGs) with a total of 635 records, while 232 strains (40.4%) exhibited multi-drug resistance. Mobile genomic elements (MGEs) serve as critical drivers for ARGs. Our dataset includes 5,636 MGEs records, with most MGEs belonging to prophages and plasmids. This dataset expands our understanding of the genomic characteristics of S. Gallinarum, providing valuable resources for future genomic studies to improve disease management.
鸡伤寒沙门氏菌（S. Gallinarum）是一种专性禽类病原体，可导致禽伤寒，这是一种严重的全身性疾病，鸡的死亡率很高。这种疾病给家禽业带来了巨大的负担，特别是在中国等发展中国家。然而，关于鸡伤寒沙门氏菌的综合基因组数据集却很缺乏。在这里，我们呈现了最广泛的鸡伤寒沙门氏菌基因组数据集，包含 574 个精心整理的样本。该数据集由 366 个在我们实验室中测序的基因组和 208 个来自过去一个世纪的不同大洲的公开基因组组成。通过计算机预测，我们将鸡伤寒沙门氏菌分为三个不同的生物变种。在抗菌药物耐药性方面，238 株（41.5%）携带抗菌药物耐药基因（ARGs），共有 635 个记录，而 232 株（40.4%）表现出多药耐药性。移动基因组元件（MGEs）是 ARGs 的关键驱动因素。我们的数据集包括 5636 个 MGEs 记录，其中大多数 MGEs 属于噬菌体和质粒。该数据集扩展了我们对鸡伤寒沙门氏菌基因组特征的理解，为未来的基因组研究提供了有价值的资源，以改善疾病管理。
