Zheng Hui-E, Wang Yun, Wu Shuhui, Zhu Ming-Fang
Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 May 29;17:1259-1263. doi: 10.2147/CCID.S463569. eCollection 2024.
Porokeratosis (PK), characterized by keratotic lesions with an atrophic center and a prominent peripheral ridge, with a typical histological hallmark, namely, the cornoid lamella, has two forms: disseminated and localized. While PK often converts into squamous cell carcinoma (SCC), conversion from disseminated superficial porokeratosis (DSP) alone is rarely reported except for one case in which DSP and LP coexisted and converted to SCC. Here, we report the case of a patient with SCC converted from DSP alone, presenting with coin-sized macules on the bottom right of his waist that developed into an ulcer at the center. The patient underwent radiation therapy, which effectively treated the SCC but did not resolve the PK. This article highlights regular follow-up and undergo comprehensive diagnosis, both of which are beneficial to enable early detection and management of DSP that has converted to into SCC; in addition, standardized medical treatment may help improve the treatment therapeutic effect of in similar diseases.
汗孔角化症（PK）的特征是角化性皮损中央萎缩、周边隆起，具有典型的组织学特征即鸡眼样板层，有播散性和局限性两种类型。虽然PK常转变为鳞状细胞癌（SCC），但除1例播散性浅表性汗孔角化症（DSP）与局限性汗孔角化症（LP）共存并转变为SCC外，单独由DSP转变而来的情况鲜有报道。在此，我们报告1例单独由DSP转变为SCC的患者，其腰部右下方出现硬币大小的斑疹，中央发展为溃疡。该患者接受了放射治疗，有效治疗了SCC，但未解决PK问题。本文强调定期随访和全面诊断，这两者都有助于早期发现和处理已转变为SCC的DSP；此外，规范化治疗可能有助于提高类似疾病的治疗效果。
