Ibbotson S H
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Clin Exp Dermatol. 1996 Jan;21(1):48-50. doi: 10.1046/j.1365-2230.1996.d01-177.x.
A female patient is presented who consistently developed lesions of disseminated superficial porokeratosis (DSP) whilst on holiday abroad. The lesions resolved completely within 4-6 weeks of return to the UK. Induction of the lesions by exposure to artificial sources of UVA and UVB was unsuccessful. Disseminated superficial porokeratosis (DSP) is thought to be a clonal disorder of keratinization and the histological hallmark is the cornoid lamella. The aetiology of DSP is unclear although it has been suggested that local or systemic immune suppression may allow the development of mutant clones of keratinocytes. Chernosky and Freeman first proposed an actinic aetiology for DSP in 1967 but the mechanism of induction is unclear.
本文报告了一位女性患者，她在国外度假期间反复出现播散性浅表性光化性角化病（DSP）皮损。回国后4 - 6周内，皮损完全消退。通过暴露于人工UVA和UVB光源诱导皮损未成功。播散性浅表性光化性角化病（DSP）被认为是一种角化的克隆性疾病，组织学特征是鸡眼样板。DSP的病因尚不清楚，尽管有人提出局部或全身免疫抑制可能使角质形成细胞的突变克隆得以发展。1967年，Chernosky和Freeman首次提出DSP的光化病因，但诱导机制尚不清楚。
