Choi Koang Hyun, Kim Tae Yoon
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Dermatol. 2009 May;21(2):150-3. doi: 10.5021/ad.2009.21.2.150. Epub 2009 May 31.
Disseminated superficial porokeratosis (DSP) is a specific disorder of keratinization. Genetic studies show that DSP is an autosomal dominant trait. Clinically, the lesions show a sharply demarcated and hyperkeratotic plaque with central atrophy. The lesions appear mainly in the extremities and generally develop with bilateral symmetry. Unusual cases of DSP accompanied by severe pruritus have been reported as "eruptive pruritic papular porokeratosis" or "inflammatory DSP." Histopathologically, inflammatory DSP is characterized by the presence of cornoid lamella with a dense infiltration of eosinophils and lymphocytes in the perivascular area of the upper dermis. Here we report a case of inflammatory DSP in a 84-year-old man with colon cancer who presented with multiple hyperpigmented atrophic macules.
播散性浅表性汗孔角化症（DSP）是一种特殊的角化异常疾病。遗传学研究表明，DSP是一种常染色体显性性状。临床上，皮损表现为边界清晰的角化过度斑块伴中央萎缩。皮损主要出现在四肢，通常呈双侧对称分布。有罕见的DSP病例伴有严重瘙痒，被报道为“爆发性瘙痒性丘疹性汗孔角化症”或“炎症性DSP”。组织病理学上，炎症性DSP的特征是存在鸡眼样板层，真皮上部血管周围区域有密集的嗜酸性粒细胞和淋巴细胞浸润。在此，我们报告一例84岁患有结肠癌的男性炎症性DSP病例，该患者出现多处色素沉着性萎缩斑。
