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以及在阿尔茨海默病样病理中棘球酸有效性的药代动力学评估。

and pharmacokinetic assessment of echinocystic acid effectiveness in Alzheimer's disease like pathology.

作者信息

S Ankul Singh, Vellapandian Chitra

机构信息

Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur, Tamil nadu, 603203, India (Bharat).

出版信息

Future Sci OA. 2024 May 23;10(1):FSO904. doi: 10.2144/fsoa-2023-0150. eCollection 2024.

Abstract

Alzheimer's disease causes dementia which impairs the cognitive domains. The pharmacokinetic characteristics and biological activity of echinocystic acid are predicted in this work using or computational approaches, including pkCSM, Swiss ADME, OSIRIS property explorer, PASS online web resource and MOLINSPIRATION software. The compound has lipid metabolism regulating property as major role in decreasing the progression of Alzheimer's disease and it has no major side effects and ADR. The drug also has anti-inflammatory properties which can help in regulating the innate immunity that plays a major role in Alzheimer's disease. From the computational screening, we infer that, echinocystic acid can regulate memory loss, cognitive disability and also slow down the progression of Alzheimer's disease-like pathology.

摘要

阿尔茨海默病会导致痴呆,损害认知领域。本研究使用计算方法,包括pkCSM、Swiss ADME、OSIRIS性质探索者、在线PASS网络资源和MOLINSPIRATION软件,预测了海胆酸的药代动力学特征和生物活性。该化合物具有调节脂质代谢的特性,在减缓阿尔茨海默病进展方面起主要作用,且无重大副作用和不良反应。该药物还具有抗炎特性,有助于调节在阿尔茨海默病中起主要作用的先天免疫。通过计算筛选,我们推断,海胆酸可以调节记忆丧失、认知障碍,并减缓阿尔茨海默病样病理的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e0b/11140647/9e2ba4de67c6/IFSO_A_2341566_F0001_C.jpg

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