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关节炎缓解:揭示浸渍油中的潜力。

Arthritis alleviation: unveiling the potential in macerated oil.

作者信息

Vijayan Sukanya, Margesan Thirumal

机构信息

Department of Pharmacognosy, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur, 603203, Chengalpattu, Tamil Nadu, India.

出版信息

Future Sci OA. 2024 May 15;10(1):FSO981. doi: 10.2144/fsoa-2023-0248. eCollection 2024.

Abstract

This study endeavors to explore the anti-arthritic effects of macerated oil derived from the plant's aerial parts. The macerated oil was prepared using maceration in coconut oil, and its phytochemical composition was elucidated using GC-MS. To assess its anti-arthritic activity, studies were conducted using various assays. The macerated oil showed better antioxidant and anti-arthritic potential by - investigations. Molecular docking studies elucidated potential binding interactions between specific constituents of the oil and critical molecular targets implicated in the pathogenesis of arthritis, further substantiating its therapeutic potential. The results demonstrated that macerated oil could ameliorate arthritis severity in a dose-dependent manner.

摘要

本研究旨在探索该植物地上部分浸制油的抗关节炎作用。浸制油通过在椰子油中浸渍制备,其植物化学成分通过气相色谱-质谱联用仪(GC-MS)进行阐明。为评估其抗关节炎活性,使用了各种分析方法进行研究。通过研究发现,浸制油显示出更好的抗氧化和抗关节炎潜力。分子对接研究阐明了油的特定成分与关节炎发病机制中涉及的关键分子靶点之间的潜在结合相互作用,进一步证实了其治疗潜力。结果表明,浸制油可以剂量依赖性方式改善关节炎严重程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/11137774/a4ffbfbbd074/IFSO_A_2340277_F0001_C.jpg

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