Terpstra Sietse E S, van de Stadt Lotte A, Berenbaum Francis, Blanco Francisco J, Haugen Ida K, Mastbergen Simon C, Weinans Harrie, Jansen Mylène P, Rosendaal Frits R, Kloppenburg Margreet
Department of Rheumatology, Leiden University Medical Center, the Netherlands.
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Osteoarthr Cartil Open. 2024 May 14;6(3):100487. doi: 10.1016/j.ocarto.2024.100487. eCollection 2024 Sep.
To investigate whether structural hand OA or its progression is associated with structural knee OA progression after two years in a population with symptomatic knee OA.
We used baseline and two-year follow-up data from the IMI-APPROACH cohort. Symptomatic hand and knee OA were defined using ACR criteria. Radiographs of hands and knees were scored semi-quantitatively for osteophytes and joint space narrowing (JSN) following the OARSI atlas, and Kellgren-Lawrence (KL) scale. Knee images were also scored quantitatively with the Knee Image Digital Analysis (KIDA). Progression was defined as change above the minimal detectable change on patient level, except for KIDA (most affected knee compartment level). With logistic regression analyses the severity or progression of hand OA was associated with knee OA progression.
In 221 participants (mean age 66, 77% women, mean BMI 27.7, 19% hand OA), OA progression occurred in 18%-28%, and 9%-38% in hands and knees respectively, depending on features. Baseline structural hand OA features were not significantly associated with knee OA progression, except for hand osteophytes with KIDA osteophytes progression (odds ratio (OR) 1.03, 95% confidence interval (CI) 1.01-1.06). Progression of structural hand OA features was not significantly associated with knee OA progression, except for hand osteophyte or JSN progression, which was significantly associated with knee osteophyte progression (OR 0.44, 95%CI 0.22-0.84 and OR 0.43, 95%CI 0.18-0.94, respectively), and hand osteophyte progression for knee JSN (OR 2.51, 95%CI 1.15-5.48).
In patients with symptomatic knee OA, no consistent associations between baseline structural hand OA or hand OA progression and knee OA progression were shown.
在有症状性膝关节骨关节炎（OA）的人群中，研究手部结构性OA或其进展与两年后膝关节OA进展是否相关。
我们使用了IMI-APPROACH队列的基线和两年随访数据。采用美国风湿病学会（ACR）标准定义有症状的手部和膝关节OA。根据骨关节炎研究学会国际（OARSI）图谱和凯尔格伦-劳伦斯（KL）分级标准，对手部和膝关节X线片的骨赘和关节间隙狭窄（JSN）进行半定量评分。膝关节图像还采用膝关节图像数字分析（KIDA）进行定量评分。进展定义为患者水平上高于最小可检测变化的改变，但KIDA评分除外（最严重的膝关节腔水平）。通过逻辑回归分析，手部OA的严重程度或进展与膝关节OA进展相关。
221名参与者（平均年龄66岁，77%为女性，平均体重指数27.7，19%有手部OA），根据特征不同，手部和膝关节OA进展分别为18%-28%和9%-38%。除手部骨赘与KIDA骨赘进展相关外（优势比（OR）1.03，95%置信区间（CI）1.01-1.06），基线结构性手部OA特征与膝关节OA进展无显著相关性。结构性手部OA特征的进展与膝关节OA进展无显著相关性，除了手部骨赘或JSN进展与膝关节骨赘进展显著相关（OR分别为0.44，95%CI 0.22-0.84和OR 0.43，95%CI 0.18-0.94），以及手部骨赘进展与膝关节JSN相关（OR 2.51，95%CI 1.15-5.48）。
在有症状性膝关节OA的患者中，未显示基线结构性手部OA或手部OA进展与膝关节OA进展之间存在一致的关联。
