Wang Shao-Ting, He Xiao-Yun, Le Juan, Sun Ting, Peng Rui
Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.
J Inflamm Res. 2024 May 27;17:3423-3431. doi: 10.2147/JIR.S463204. eCollection 2024.
Hypovitaminosis K has been linked to depression and suicide, but epidemiological research is scarce. This study aimed to explore the association among vitamin K with depression and suicidal attempts.
This was a retrospective cross-sectional study involving 146 cases with a history of suicidal attempts and 149 subjects without a lifetime history of suicidal attempts. The levels of thyroid hormones, lipid profile, inflammatory cytokines, and vitamins were measured.
Subjects who had suicidal attempts presented with a significant decrease in FT4, TC, vitamin D, and vitamin K but increased CRP levels. In these variables, vitamin K has a better diagnostic value for suicidal attempts in depressed patients, with a sensitivity of 0.842 and a specificity of 0.715. Correlation analysis suggested that vitamin K was significantly and positively related to FT4, TC, LDL, and sdLDL. Multivariate analysis showed that serum vitamin K level predicts suicidal attempts in depressive patients (OR = 0.614, = 0.004, 95% CI 0.153-0.904). Moreover, a negative correlation between vitamin K and suicidal attempts was also noted for partial FT4, CRP, and vitamin D strata analysis.
Our study suggests that low vitamin K levels were correlated with suicidal attempts in patients with depression, indicating that vitamin K deficiency might be a biological risk factor for depression.
维生素K缺乏症与抑郁症和自杀有关，但流行病学研究较少。本研究旨在探讨维生素K与抑郁症及自杀未遂之间的关联。
这是一项回顾性横断面研究，纳入了146例有自杀未遂史的患者和149例无自杀未遂史的受试者。检测了甲状腺激素、血脂、炎症细胞因子和维生素水平。
有自杀未遂史的受试者FT4、总胆固醇（TC）、维生素D和维生素K水平显著降低，但C反应蛋白（CRP）水平升高。在这些变量中，维生素K对抑郁症患者自杀未遂具有更好的诊断价值，敏感性为0.842，特异性为0.715。相关性分析表明，维生素K与FT4、TC、低密度脂蛋白（LDL）和小而密低密度脂蛋白（sdLDL）显著正相关。多因素分析显示，血清维生素K水平可预测抑郁症患者的自杀未遂情况（比值比[OR]=0.614，P=0.004，95%可信区间[CI]0.153-0.904）。此外，在部分FT4、CRP和维生素D分层分析中，也发现维生素K与自杀未遂呈负相关。
我们的研究表明，抑郁症患者维生素K水平低与自杀未遂有关，提示维生素K缺乏可能是抑郁症的一个生物学危险因素。
