Akhter Mst Sanjida, Rahman Md Ataur, Ripon Rezaul Karim, Mubarak Mahfuza, Akter Mahmuda, Mahbub Shamim, Al Mamun Firoj, Sikder Md Tajuddin
Health and Environmental Epidemiology Laboratory (HEEL), Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.
Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, Bangladesh.
Heliyon. 2024 May 1;10(11):e29766. doi: 10.1016/j.heliyon.2024.e29766. eCollection 2024 Jun 15.
Nanoparticles have recently become considered as a crucial player in contemporary medicine, with therapeutic uses ranging from contrast agents in imaging to carriers for the transport of drugs and genes into a specific target. Nanoparticles have the ability to have more precise molecular interactions with the human body in order to target specific cells and tissues with minimal adverse effects and maximal therapeutic outcomes. With the least number of side effects and the greatest possible therapeutic benefit, nanoparticles can target particular cells and tissues through more precise molecular interactions with the human body. The majority of global public health problems are now treated with green synthesized silver nanoparticles (AgNPs), which substantially affect the fundamental structure of DNA and proteins and thus display their antimicrobial action. AgNPs can inhibit the proliferation of tumor cells and induce oxidative stress. By inhibiting vascular endothelial growth factor (HIF)-1, pro-inflammatory mediators generated by silver nanoparticles are reduced, mucin hypersecretion is lessened, and gene activity is subsequently regulated to prevent infections. The biogenic synthesis of silver nanoparticles (AgNPs) using various plants and their applications in antibacterial, antifungal, antioxidant, anticancer, anti-inflammatory, and antidiabetic activities have been extensively discussed in this article. Also, because only natural substances are utilized in the manufacturing process, the particles that are created naturally are coated, stabilized, and play a vital role in these biomedical actions. The characterization of AgNPs, possibility of preparing AgNPSs with different shapes using biological method and their impact on functions and toxicities, impact of size, shape and other properties on AgNPs functions and toxicity profiles, limitations, and future prospects of green-mediated AgNPs have also been reported in this study. The major goal of this study is to provide readers with a comprehensive, informed, and up-to-date summary of the various AgNPs production and characterization methods and their under-investigational antioxidant, antibacterial, and anticancer, antidiabetic, antifungal and anti-inflammatory properties. This review provides instructions and suggestions for additional studies based on AgNPs. This evaluation also pushes researchers to look into natural resources like plant parts in order to create useful nanobiotechnology.
纳米颗粒最近已被视为当代医学中的关键角色，其治疗用途广泛，从成像中的造影剂到将药物和基因输送到特定靶点的载体。纳米颗粒能够与人体进行更精确的分子相互作用，从而以最小的副作用和最大的治疗效果靶向特定的细胞和组织。纳米颗粒可以通过与人体更精确的分子相互作用靶向特定的细胞和组织，副作用最少且治疗益处最大。目前，大多数全球公共卫生问题都采用绿色合成银纳米颗粒（AgNPs）进行治疗，其会显著影响DNA和蛋白质的基本结构，从而发挥抗菌作用。AgNPs可以抑制肿瘤细胞的增殖并诱导氧化应激。通过抑制血管内皮生长因子（HIF）-1，银纳米颗粒产生的促炎介质减少，粘蛋白分泌过多的情况减轻，随后基因活性得到调节以预防感染。本文广泛讨论了使用各种植物生物合成银纳米颗粒（AgNPs）及其在抗菌、抗真菌、抗氧化、抗癌、抗炎和抗糖尿病活性方面的应用。此外，由于在制造过程中仅使用天然物质，天然生成的颗粒会被包覆、稳定化，并在这些生物医学作用中发挥重要作用。本研究还报道了AgNPs的表征、使用生物方法制备不同形状AgNPSs的可能性及其对功能和毒性的影响、尺寸、形状和其他性质对AgNPs功能和毒性特征的影响、局限性以及绿色介导的AgNPs的未来前景。本研究的主要目标是为读者提供关于各种AgNPs生产和表征方法及其正在研究的抗氧化、抗菌、抗癌、抗糖尿病、抗真菌和抗炎特性的全面、详实且最新的综述。本综述为基于AgNPs的进一步研究提供了指导和建议。该评估还促使研究人员探索植物部位等自然资源，以创造有用的纳米生物技术。
