Kunin C M
J Infect Dis. 1985 Mar;151(3):388-98. doi: 10.1093/infdis/151.3.388.
Antimicrobial agents are a critical element of the therapeutic armamentarium of modern medicine. How well they are used reflects our ability to treat and prevent infectious diseases. The major consideration for proper usage is to select the optimal agent at the proper dosage. Secondary, but important concerns are to minimize the emergence of resistance and to provide health services at a reasonable cost. The infectious disease community must work in concert with the pharmaceutical industry to achieve these goals. The relations of infectious disease physicians with the industry have been remarkably effective in evaluating and introducing new drugs, however, it is natural that conflicts should arise. Although the overall accomplishments have been outstanding, there is considerable evidence that antimicrobial agents are often abused and used excessively. This paper outlines some of the issues of marketing and the problems inherent in industry-sponsored trials. As specialties other than infectious diseases have encountered major difficulties, it is timely that this society adopts a code of ethical conduct for its work with industrial sponsors and takes the initiative in developing programs for education of other physicians in the field of infectious diseases and antimicrobial therapy both in this country and in developing nations.
抗菌药物是现代医学治疗手段的关键要素。它们的使用效果反映了我们治疗和预防传染病的能力。合理使用的主要考量是在适当剂量下选择最佳药物。其次但同样重要的是，要尽量减少耐药性的出现，并以合理成本提供医疗服务。传染病领域必须与制药行业协同合作以实现这些目标。传染病医生与制药行业的关系在评估和引入新药方面一直卓有成效，然而，冲突的出现实属自然。尽管总体成就斐然，但有大量证据表明抗菌药物经常被滥用和过度使用。本文概述了一些营销问题以及行业赞助试验中固有的问题。鉴于传染病以外的其他专业领域遇到了重大困难，本学会适时地为其与行业赞助商的合作制定道德行为准则，并主动开展项目，对本国和发展中国家的其他医生进行传染病和抗菌治疗领域的教育。
