Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) - Guwahati, Changsari, Kamrup, Assam, 781101, India.
Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528, Athens, Greece.
Chem Biodivers. 2024 Aug;21(8):e202400709. doi: 10.1002/cbdv.202400709. Epub 2024 Jul 16.
Biochanin A, an isoflavone flavonoid with estrogenic activity, is naturally found in red clover and other legumes. It possesses a wide range of pharmacological properties, including antioxidant, anti-inflammatory, anti-apoptotic, neuroprotective, and anticancer effects. In recent years, a growing body of pre-clinical research has focused on exploring the therapeutic potential of biochanin A in various neurological disorders, such as Alzheimer's and Parkinson's disease, multiple sclerosis, epilepsy, ischemic brain injury, gliomas, and neurotoxicity. This comprehensive review aims to shed light on the underlying molecular mechanisms that contribute to the neuroprotective role of biochanin A based on previous pre-clinical studies. Furthermore, it provides a detailed overview of the protective effects of biochanin A in diverse neurological disorders. The review also addresses the limitations associated with biochanin A administration and discusses different approaches employed to overcome these challenges. Finally, it highlights the future opportunities for translating biochanin A from pre-clinical research to clinical studies while also considering its commercial viability as a dietary supplement or a potential treatment for various diseases.
染料木黄酮 A 是一种具有雌激素活性的异黄酮类黄酮，天然存在于红三叶草和其他豆类植物中。它具有广泛的药理特性，包括抗氧化、抗炎、抗细胞凋亡、神经保护和抗癌作用。近年来，越来越多的临床前研究集中在探索染料木黄酮 A 在各种神经疾病中的治疗潜力，如阿尔茨海默病和帕金森病、多发性硬化症、癫痫、缺血性脑损伤、神经胶质瘤和神经毒性。本综述旨在根据以前的临床前研究，阐明染料木黄酮 A 发挥神经保护作用的潜在分子机制。此外，它还详细介绍了染料木黄酮 A 在多种神经疾病中的保护作用。该综述还讨论了与染料木黄酮 A 给药相关的局限性，并讨论了克服这些挑战所采用的不同方法。最后，它强调了将染料木黄酮 A 从临床前研究转化为临床研究的未来机会，同时考虑将其作为膳食补充剂或治疗各种疾病的潜在治疗方法的商业可行性。
