蒺藜酰胺类化合物及其对 RAW 264.7 细胞一氧化氮生成的抑制作用。

Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells.

机构信息

College of Pharmacy, Chungbuk National University, Cheongju, 28160, Korea.

College of Agriculture, Life and Environmental Sciences, Chungbuk National University, Cheongju, 28644, Korea.

出版信息

Arch Pharm Res. 2018 Feb;41(2):192-195. doi: 10.1007/s12272-017-0984-0. Epub 2017 Nov 25.

DOI:10.1007/s12272-017-0984-0

PMID:29177586

Abstract

A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC values of 18.7-49.4 μM.

摘要

从蒺藜果实的甲醇提取物中分离得到一种新的酚酰胺，命名为顺式陆地酰胺（7），以及另外 10 种已知化合物（1-6、8-11）。根据 1D 和 2D 核磁共振波谱和高分辨质谱数据的广泛分析，确定了 7 的结构。化合物 1、2、5、6、8、9 和 11 对 RAW 264.7 细胞中脂多糖刺激的一氧化氮生成具有抑制作用，IC 值为 18.7-49.4 μM。