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2
Characterization of Differentially Detectable Mycobacterium tuberculosis in the Sputum of Subjects with Drug-Sensitive or Drug-Resistant Tuberculosis before and after Two Months of Therapy.在接受两个月治疗前后，药物敏感或耐药结核病患者痰液中可检测到的结核分枝杆菌的特征。
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0060821. doi: 10.1128/AAC.00608-21.
3
Detection of differentially culturable tubercle bacteria in sputum using mycobacterial culture filtrates.使用分枝杆菌培养滤液检测痰液中可培养的结核分枝杆菌。
Sci Rep. 2021 Mar 22;11(1):6493. doi: 10.1038/s41598-021-86054-z.
4
Early Bactericidal Activity Trial of Nitazoxanide for Pulmonary Tuberculosis.硝唑尼特治疗肺结核的早期杀菌活性试验。
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.01956-19.
5
Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment.海地未经治疗的受试者痰液中可检测到的结核分枝杆菌细胞及其在治疗开始后比例的增加。
mBio. 2018 Nov 20;9(6):e02192-18. doi: 10.1128/mBio.02192-18.
6
Rifamycin action on RNA polymerase in antibiotic-tolerant results in differentially detectable populations.利福霉素对耐抗生素 RNA 聚合酶的作用导致可检测到的群体存在差异。
Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840. doi: 10.1073/pnas.1705385114. Epub 2017 May 30.
7
The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations.结核分枝杆菌 MGIT 阳性时间与痰标本中菌落形成单位的关系表明细菌表型发生变化，可能反映了化疗对关键亚群的影响。
J Antimicrob Chemother. 2015 Feb;70(2):448-55. doi: 10.1093/jac/dku415. Epub 2014 Oct 25.
8
Time to positivity in liquid culture predicts colony forming unit counts of Mycobacterium tuberculosis in sputum specimens.液体培养阳性时间可预测痰标本中结核分枝杆菌的集落形成单位计数。
Tuberculosis (Edinb). 2014 Mar;94(2):148-51. doi: 10.1016/j.tube.2013.12.002. Epub 2013 Dec 18.
9
Comparison of time to positive and colony counting in an early bactericidal activity study of anti-tuberculosis treatment.抗结核治疗早期杀菌活性研究中阳性和菌落计数时间的比较。
Int J Tuberc Lung Dis. 2013 Nov;17(11):1448-51. doi: 10.5588/ijtld.13.0063.
10
Persister populations of Mycobacterium tuberculosis in sputum that grow in liquid but not on solid culture media.痰液中分枝杆菌的持久菌种群，在液体中生长但不在固体培养基上生长。
J Antimicrob Chemother. 2014 Feb;69(2):437-40. doi: 10.1093/jac/dkt357. Epub 2013 Sep 26.

在细菌负荷低且分枝杆菌检测能力不同的情况下， 的定量存在很大差异。

High variance in quantification of at low bacterial loads and with differentially detectable mycobacteria.

机构信息

Center for Global Health, Weill Cornell Medicine, New York, New York, USA.

Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.

出版信息

Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0160123. doi: 10.1128/aac.01601-23. Epub 2024 Jun 3.

DOI:10.1128/aac.01601-23
PMID:38829050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11232379/
Abstract

We examined the correlation between three different methods of quantification: time to positivity (TTP), log CFU, and an assay to detect differentially detectable (DD Mtb) from three different prospective studies. Participants with DD Mtb have significantly more variation in the CFU/TTP correlation than participants with no DD Mtb ( < 0.001). This may impact the design of early bactericidal activity studies that use TTP as the primary outcome.

摘要

我们研究了三种不同定量方法

阳性时间（TTP）、logCFU 和检测差异可检测 (DD Mtb) 的检测，它们与三项前瞻性研究相关。与无 DD Mtb 的参与者相比，DD Mtb 参与者的 CFU/TTP 相关性变化更大（<0.001）。这可能会影响使用 TTP 作为主要结局的早期杀菌活性研究的设计。