Gülhane School of Medicine, Department of Neurology, University of Health Sciences, Ankara, Turkey.
Gülhane Faculty of Physiotherapy and Rehabilitation, University of Health Sciences, Ankara, Turkey.
Ideggyogy Sz. 2024 May 30;77(5-6):187-195. doi: 10.18071/isz.77.0187.
Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder characterized by contradictory clinical outcomes among its several subtypes. The disease can manifest with a tremor-dominant (TD) or a non-tremor-dominant (NTD) phenotype. Although the TD subtype may show a better prognosis, there is limited information on the phenotypic differences regarding the level of axial symptoms. For this reason, in this study it was aimed to make a quantitative comparison of axial posture and spinal mobility between PD with TD and NTD.
.This case-control study was conducted on 94 patients with diagnosed PD. A group diagnosis approach was used in the study, such that the diagnosis of each patient was confirmed, and they were assig-ned to TD and NTD groups by a neurologist expert on movement disorders. Of the patients with PD, 61 were in the TD group, and 33 were in the NTD group. Spinal mouse was used to measure spinal posture and spinal mobility in both sagittal and frontal planes.
.Two groups of 61 patients (25 male + 36 female) with TD-PD (mean age: 64.49±10.37 years) and 33 patients (20 male +13 female) with NTD-PD (mean age: 63.45±9.11 years) were enrolled in the study. There were no significant differences between the patients with TD and NTD in terms of sagittal and frontal postures (p>0.05). In addition to this, anterior trunk tilt was found to significantly increase as the disease stage advanced in both groups. While the greatest anterior trunk tilt change in the TD-PD group was observed in the 3rd stage, NTD-PD group was in the 2.5th stage. Aside from this, the outcomes of the spinal mobility measurements in the frontal and sagittal planes were similar between the groups (p>0.05).
.It is widely acknowledged that many clinical aspects of the TD and NTD forms of PD differ; however, in our study, it was observed that there may be no difference in the axial symptoms of the patients with PD in terms of classification according to tremor dominance.
.帕金森病（PD）是一种异质性神经退行性疾病，其几种亚型的临床结果存在矛盾。该疾病可能表现为震颤主导型（TD）或非震颤主导型（NTD）表型。虽然 TD 亚型可能显示出更好的预后，但关于轴性症状水平的表型差异的信息有限。出于这个原因，在这项研究中，旨在对 TD 和 NTD 帕金森病患者的轴向姿势和脊柱活动度进行定量比较。
这项病例对照研究纳入了 94 名确诊的 PD 患者。在研究中采用了分组诊断方法，由运动障碍专家对每位患者进行诊断，并将他们分配到 TD 和 NTD 组。在 PD 患者中，61 例为 TD 组，33 例为 NTD 组。使用脊柱鼠测量矢状面和额状面的脊柱姿势和脊柱活动度。
两组患者分别为 61 例（25 例男性+36 例女性）TD-PD（平均年龄：64.49±10.37 岁）和 33 例（20 例男性+13 例女性）NTD-PD（平均年龄：63.45±9.11 岁）。TD 和 NTD 患者在矢状面和额状面姿势方面无显著差异（p>0.05）。此外，在两组中，随着疾病阶段的进展，前躯干倾斜显著增加。虽然在 TD-PD 组中观察到最大的前躯干倾斜变化发生在第 3 阶段，而在 NTD-PD 组中则发生在第 2.5 阶段。除此之外，两组患者在额状面和矢状面的脊柱活动度测量结果相似（p>0.05）。
广泛认为 TD 和 NTD 形式的 PD 在许多临床方面存在差异；然而，在我们的研究中，观察到根据震颤主导性对 PD 患者进行分类时，其轴性症状可能没有差异。
