Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Laoshan District, Qingdao, Shandong, China.
Qingdao Municipal Center for Disease Control and Prevention, Shibei District, Qingdao, Shandong, China.
PLoS One. 2024 Jun 3;19(6):e0304770. doi: 10.1371/journal.pone.0304770. eCollection 2024.
Age-related hearing loss is a complex disease caused by a combination of genetic and environmental factors, and a study have conducted animal experiments to explore the association between BCL11B heterozygosity and age-related hearing loss. The present study used established genetic models to examine the association between BCL11B gene polymorphisms and age-related hearing loss. A total of 410 older adults from two communities in Qingdao, China, participated in this study. The case group comprised individuals aged ≥ 60 years with age-related hearing loss, and the control group comprised individuals without age-related hearing loss from the same communities. The groups were matched 1:1 for age and sex. The individual characteristics of the participants were analyzed descriptively using the Mann-Whitney U test and the chi-square test. To explore the association between BCL11B gene polymorphisms and age-related hearing loss, conditional logistic regression was performed to construct genetic models for two single-nucleotide-polymorphisms (SNPs) of BCL11B, and haplotype analysis was conducted to construct their haplotype domains. Two SNP sites of the BCL11B gene, four genetic models of rs1152781 (additive, dominant, recessive, and codominant), and five genetic models of rs1152783 (additive, dominant, recessive, codominant, and over dominant) were significantly associated with age-related hearing loss in the models both unadjusted and adjusted for all covariates (P < 0.05). Additionally, a linkage disequilibrium between rs1152781 and rs1152783 was revealed through haplotype analysis. Our study revealed that BCL11B gene polymorphisms were significantly associated with age-related hearing loss.
年龄相关性听力损失是一种由遗传和环境因素共同作用引起的复杂疾病，有研究对动物进行了实验，以探讨 BCL11B 杂合性与年龄相关性听力损失之间的关联。本研究使用已建立的遗传模型来检验 BCL11B 基因多态性与年龄相关性听力损失之间的关联。共有来自中国青岛两个社区的 410 名老年人参与了这项研究。病例组由年龄≥60 岁且患有年龄相关性听力损失的个体组成，对照组由来自同一社区且无年龄相关性听力损失的个体组成。两组在年龄和性别上按 1:1 匹配。采用 Mann-Whitney U 检验和卡方检验对参与者的个体特征进行描述性分析。为了探讨 BCL11B 基因多态性与年龄相关性听力损失之间的关联，采用条件逻辑回归构建了 BCL11B 两个单核苷酸多态性（SNP）的遗传模型，并进行了单体型分析以构建其单体型域。BCL11B 基因的两个 SNP 位点 rs1152781（加性、显性、隐性和共显性）的四个遗传模型，以及 rs1152783（加性、显性、隐性、共显性和超显性）的五个遗传模型，在未调整和调整所有协变量的模型中均与年龄相关性听力损失显著相关（P < 0.05）。此外，通过单体型分析揭示了 rs1152781 和 rs1152783 之间的连锁不平衡。本研究表明，BCL11B 基因多态性与年龄相关性听力损失显著相关。
