更多证据表明，非水髓鞘脂质可在临床 3T 扫描仪上通过超短回波时间（UTE）MRI 直接成像：冻干红细胞膜脂质研究。
Yet more evidence that non-aqueous myelin lipids can be directly imaged with ultrashort echo time (UTE) MRI on a clinical 3T scanner: a lyophilized red blood cell membrane lipid study.
机构信息
Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
Department of Radiology, University of California, San Diego, La Jolla, CA, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
出版信息
Neuroimage. 2024 Aug 1;296:120666. doi: 10.1016/j.neuroimage.2024.120666. Epub 2024 Jun 1.
Direct imaging of semi-solid lipids, such as myelin, is of great interest as a noninvasive biomarker of neurodegenerative diseases. Yet, the short T relaxation times of semi-solid lipid protons hamper direct detection through conventional magnetic resonance imaging (MRI) pulse sequences. In this study, we examined whether a three-dimensional ultrashort echo time (3D UTE) sequence can directly acquire signals from membrane lipids. Membrane lipids from red blood cells (RBC) were collected from commercially available blood as a general model of the myelin lipid bilayer and subjected to DO exchange and freeze-drying for complete water removal. Sufficiently high MR signals were detected with the 3D UTE sequence, which showed an ultrashort T* of ∼77-271 µs and a short T of ∼189 ms for semi-solid RBC membrane lipids. These measurements can guide designing UTE-based sequences for direct in vivo imaging of membrane lipids.
直接对类脂半固体（如髓磷脂）成像，作为神经退行性疾病的一种非侵入性生物标志物具有重要意义。然而，类脂半固体质子的短 T2 弛豫时间阻碍了通过传统磁共振成像（MRI）脉冲序列进行直接检测。在这项研究中，我们研究了三维超短回波时间（3D UTE）序列是否可以直接采集膜脂的信号。从市售血液中收集红细胞（RBC）的膜脂作为髓磷脂类脂双层的一般模型，并进行 DO 交换和冷冻干燥以完全去除水分。3D UTE 序列检测到了足够高的 MR 信号，对于类脂半固体 RBC 膜，其 T*为约 77-271µs，T1 为约 189ms。这些测量结果可以为基于 UTE 的直接在体成像膜脂的序列设计提供指导。
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