癌症研究史：致癌转录因子。
A History of Cancer Research: Oncogenic Transcription Factors.
机构信息
Departments of Pathology, Genetics, and Biology, Stanford University, Stanford, California 94305-5324, USA
出版信息
Cold Spring Harb Perspect Biol. 2024 Jun 3;16(6):a035881. doi: 10.1101/cshperspect.a035881.
Transcription factors play crucial roles in cancer, and oncogenic counterparts of cellular transcription factors are present in a number of tumor viruses. It was studies in the early 1980s that first showed tumor viruses could encode nuclear as well as cytoplasmic oncoproteins. Subsequent work provided detailed insight into their mechanisms of action, as well as potential therapeutic avenues. In this excerpt from his forthcoming book on the history of cancer research, Joe Lipsick looks back at early work on nuclear oncogenes, including the discovery of MYC, MYB, FOS and JUN, Rel/NF-κB, and nuclear receptors such as the retinoic acid receptor and thyroid hormone receptor.
转录因子在癌症中发挥着至关重要的作用，细胞转录因子的致癌对应物存在于许多肿瘤病毒中。早在 20 世纪 80 年代的研究就首次表明，肿瘤病毒可以编码核内和细胞质的癌蛋白。随后的工作深入了解了它们的作用机制，以及潜在的治疗途径。在这本即将出版的关于癌症研究历史的书中，乔·利普西克（Joe Lipsick）回顾了早期关于核癌基因的工作，包括 MYC、MYB、FOS 和 JUN、Rel/NF-κB 以及核受体（如视黄酸受体和甲状腺激素受体）的发现。
Zotero 插件