认知障碍的网络结构：从主观认知下降到阿尔茨海默病。
The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer's Disease.
机构信息
Human and Social Sciences Department, University of Salento, Lecce 73100, Italy.
Psychology Department, University of Milano-Bicocca, Milano 20126, Italy.
出版信息
J Neurosci. 2024 Jul 3;44(27):e1344232023. doi: 10.1523/JNEUROSCI.1344-23.2023.
It was proposed that a reorganization of the relationships between cognitive functions occurs in dementia, a vision that surpasses the idea of a mere decline of specific domains. The complexity of cognitive structure, as assessed by neuropsychological tests, can be captured by exploratory graph analysis (EGA). EGA was applied to the neuropsychological assessment of people (humans) with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD; total = 638). Both sexes were included. In AD, memory scores detach from the other cognitive functions, and memory subdomains reduce their reciprocal relation. SCD showed a pattern of segregated neuropsychological domains, and MCI showed a noisy and less stable pattern. Results suggest that AD drives a reorganization of cognitive functions toward a less-fractionated architecture compared with preclinical conditions. Cognitive functions show a reorganization that goes beyond the performance decline. Results also have clinical implications in test interpretations and usage.
有人提出，在痴呆症中，认知功能之间的关系会发生重组，这种观点超越了单纯特定领域衰退的观点。通过神经心理学测试评估的认知结构的复杂性，可以通过探索性图分析（EGA）来捕捉。EGA 应用于有主观认知下降（SCD）、轻度认知障碍（MCI）和阿尔茨海默病（AD；共 638 人）的人的神经心理学评估。包括男女两性。在 AD 中，记忆评分与其他认知功能分离，记忆子领域减少了它们的相互关系。SCD 表现出分离的神经心理学领域模式，而 MCI 表现出嘈杂和不太稳定的模式。结果表明，与临床前条件相比，AD 导致认知功能朝着更少分散的结构进行重组。认知功能的重组超出了表现下降的范围。结果在测试解释和使用方面也具有临床意义。
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