Tashiro N, Tanaka T, Fukumoto T, Hirata K, Nakao H
Life Sci. 1985 Mar 18;36(11):1087-94. doi: 10.1016/0024-3205(85)90494-1.
As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clarify the behavior accompanying ECG changes, in particular poststimulus arrhythmias. Forty-one of 84 points elicited behavioral patterns such as defense reaction, pseudo-rage and restlessness (classified as group A), and in twenty-one (51%) of these 41 points arrhythmias occurred after cessation of stimulation. Forty-three of 84 points elicited behavioral patterns including predatory, exploratory and other behavioral responses (classified as group B), and in three (7%) of 43 points, poststimulus arrhythmias followed. Under light anesthesia, stimulations of twofold current intensity were applied at these points, and the incidences of the arrhythmias did not change in either group. The arrhythmia-inducing area in the cases of group A was found to lie dorsal and caudal to the optic chiasma and to extend caudally in the fornix. Three points in the cases of group B were located in the outer area of the aforementioned area. These studies showed that arrhythmias and group A behavior were observed mainly from stimulation of the anterior hypothalamus, whereas stimulation of other areas of the hypothalamus, including the lateral and the posterolateral hypothalamus, produced group B behavior and no arrhythmias.
由于对下丘脑刺激所诱发的情绪行为与心电图（ECG）变化之间的关系了解甚少，通过长期植入的电极对清醒猫下丘脑内不同区域的84个点进行电刺激，目的是阐明伴随心电图变化的行为，尤其是刺激后心律失常。84个点中有41个引发了诸如防御反应、假怒和不安等行为模式（归类为A组），在这41个点中的21个（51%），刺激停止后出现了心律失常。84个点中有43个引发了包括捕食、探索和其他行为反应在内的行为模式（归类为B组），在43个点中的3个（7%），刺激后出现了心律失常。在轻度麻醉下，对这些点施加两倍电流强度的刺激，两组中心律失常的发生率均未改变。发现A组病例中诱发心律失常的区域位于视交叉的背侧和尾侧，并在穹窿中向尾侧延伸。B组病例中的三个点位于上述区域的外侧。这些研究表明，心律失常和A组行为主要是由下丘脑前部的刺激引起的，而下丘脑其他区域（包括外侧和后外侧下丘脑）的刺激则产生B组行为且无心律失常。
