Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Department of Plastic Surgery, No. 987 Hospital, Joint Logistics Support Force of PLA, No. 45 Dongfeng Road, Baoji, 721045, China.
Aesthetic Plast Surg. 2024 Aug;48(16):3147-3153. doi: 10.1007/s00266-024-04126-7. Epub 2024 Jun 3.
Skin incision scars are cosmetically displeasing; the effects of current treatments are limited, and new methods to reduce scar formation need to be found.
We sought to determine whether immediate postoperative injection of stromal vascular fraction gel (SVF-gel) could reduce scar formation at skin incision sites.
A prospective, randomized, double-blind, self-controlled trial was conducted in patients who underwent breast reduction. SVF-gel was intradermally injected into the surgical incision on one randomly selected side, with the other side receiving saline as a control. At the 6-month follow-up, the incision scars were evaluated using the Vancouver scar scale (VSS) and visual analog scale (VAS). Antera 3D camera was used for objective evaluation.
The VSS score and VAS score were significantly different between the SVF-gel-treated side (3.80 ± 1.37, 3.37±1.25) and the control side (5.25 ± 1.18, 4.94 ± 1.28). Moreover, the SVF-gel-treated side showed statistically significant improvements in scar appearance, based on evidences from Antera 3D camera.
This was a single-center, single-race, and single-gender study. Furthermore, the results were available only for the 6-month interim follow-up period.
Postoperative immediate SVF-gel injection in surgical incisions can reduce scar formation, and exert a preventive effect on scars.
Evidence obtained from at least one properly designed randomized controlled trial. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
皮肤切口疤痕不美观；目前治疗方法的效果有限，需要寻找新的方法来减少疤痕形成。
我们旨在确定术后即刻注射基质血管成分凝胶（SVF-gel）是否可以减少切口处的疤痕形成。
这是一项在接受乳房缩小术的患者中进行的前瞻性、随机、双盲、自身对照试验。SVF-gel 被皮内注射到一侧随机选择的手术切口，另一侧注射生理盐水作为对照。在 6 个月的随访中，使用温哥华疤痕量表（VSS）和视觉模拟量表（VAS）评估切口疤痕。使用 Antera 3D 相机进行客观评估。
SVF-gel 治疗侧（3.80 ± 1.37，3.37±1.25）与对照组（5.25 ± 1.18，4.94 ± 1.28）的 VSS 评分和 VAS 评分差异有统计学意义。此外，基于 Antera 3D 相机的证据，SVF-gel 治疗侧的疤痕外观有明显改善。
这是一项单中心、单种族、单性别研究。此外，结果仅可用于 6 个月的中期随访。
术后即刻在手术切口内注射 SVF-gel 可以减少疤痕形成，并对疤痕产生预防作用。
证据等级 I：至少有一项设计合理的随机对照试验获得的证据。本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述，请参阅目录或在线投稿须知 www.springer.com/00266 。
