Department of Health Studies, University of Stavanger, Norway.
Med Hypotheses. 2011 Jul;77(1):7-10. doi: 10.1016/j.mehy.2011.03.011. Epub 2011 Mar 27.
Obesity is a global public health challenge that increases the risk of various diseases including type 2 diabetes mellitus, hypertension and cancer, and will in the future cause further increases in the incidence of chronic disease. Understanding the mechanisms of obesity is critical if we are to prevent and treat this pandemic challenge. Diet and physical activity have traditionally been the major tasks in preventing and treating obesity. However, other mechanisms are now also being considered in the quest for knowledge and understanding of obesity, including the body's stress system and cortisol release. While it seems evident that stress is a cause of obesity, whether stress is also a consequence of obesity has up to now only briefly been discussed. The aim of this article is to elucidate how stress and obesity might be linked and discuss the cause/consequence relationship between the stress response and obesity. Our hypothesis is that stress and obesity interfere by positive feedback. This may be an important issue in both our understanding and coping of obesity.
肥胖是一个全球性的公共健康挑战，它增加了多种疾病的风险，包括 2 型糖尿病、高血压和癌症，并且将来还会导致慢性病发病率进一步上升。如果我们要预防和治疗这一流行疾病，了解肥胖的机制至关重要。饮食和体育锻炼一直是预防和治疗肥胖的主要任务。然而，在寻求肥胖相关知识和理解的过程中，现在也在考虑其他机制，包括身体的应激系统和皮质醇的释放。虽然压力似乎是肥胖的一个原因，但压力是否也是肥胖的后果，到目前为止，这只是一个简短的讨论。本文的目的是阐明压力和肥胖之间可能存在的联系，并讨论应激反应与肥胖之间的因果关系。我们的假设是，压力和肥胖通过正反馈相互干扰。这在我们对肥胖的理解和应对中可能是一个重要问题。
