Crespi C L, Seixas G M, Turner T R, Ryan C G, Penman B W
Mutat Res. 1985 Mar;142(3):133-40. doi: 10.1016/0165-7992(85)90053-3.
1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) were tested for the ability to induce gene mutations in two human lymphoblastoid cell lines, designated AHH-1 and TK6. Both chemicals were 'direct-acting' mutagens in both cell lines. DBE was essentially equally mutagenic in TK6 cells and AHH-1 cells. In contrast, DCE was 25-fold more mutagenic in the AHH-1 cell line than in the TK6 cell line. This differential sensitivity between AHH-1 cells and TK6 cells was related to the levels of glutathione S-transferase activity in these two cell lines.
对1,2 - 二氯乙烷（DCE）和1,2 - 二溴乙烷（DBE）在两种人淋巴母细胞系（分别命名为AHH - 1和TK6）中诱导基因突变的能力进行了测试。在这两种细胞系中，这两种化学物质均为“直接作用”诱变剂。DBE在TK6细胞和AHH - 1细胞中的诱变作用基本相同。相比之下，DCE在AHH - 1细胞系中的诱变活性比在TK6细胞系中高25倍。AHH - 1细胞和TK6细胞之间的这种差异敏感性与这两种细胞系中谷胱甘肽S - 转移酶的活性水平有关。
