Chauhan Prashant, Pandey Pratibha, Ramniwas Seema, Khan Fahad, Maqsood Ramish
Department of Biotechnology, Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh, India.
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Endocr Metab Immune Disord Drug Targets. 2025;25(4):291-299. doi: 10.2174/0118715303301146240522095638.
Lung cancer and tuberculosis (TB) are classified as the second-most life-threatening diseases globally. They both are exclusively represented as major public health risks and might exhibit similar symptoms, occasionally diagnosed simultaneously. Several epidemiological studies suggest that TB is a significant risk factor for the progression of lung cancer. The staggering mortality rates of pulmonary disorders are intrinsically connected to lung cancer and TB. Numerous factors play a pivotal role in the development of TB and may promote lung carcinogenesis, particularly among the geriatric population. Understanding the intricacies involved in the association between lung carcinogenesis and TB has become a crucial demand of current research. Consequently, this study aims to comprehensively review current knowledge on the relationship between tuberculosis-related inflammation and the emergence of lung carcinoma, highlighting the impact of persistent inflammation on lung tissue, immune modulation, fibrosis, aspects of reactive oxygen species, and an altered microenvironment that are linked to the progression of tuberculosis and subsequently trigger lung carcinoma.
肺癌和肺结核（TB）被列为全球第二大致命性疾病。它们都被视为主要的公共卫生风险，且可能表现出相似症状，偶尔会同时被诊断出来。多项流行病学研究表明，结核病是肺癌进展的一个重要风险因素。肺部疾病惊人的死亡率与肺癌和结核病有着内在联系。众多因素在结核病的发展中起着关键作用，并可能促进肺癌的发生，尤其是在老年人群中。了解肺癌发生与结核病之间关联的复杂性已成为当前研究的一项关键需求。因此，本研究旨在全面综述目前关于结核相关炎症与肺癌发生之间关系的知识，强调持续炎症对肺组织、免疫调节、纤维化、活性氧相关方面以及与结核病进展相关并随后引发肺癌的改变的微环境的影响。
