Barac Aleksandra, Vujovic Ankica, Drazic Ana, Stevanovic Goran, Paglietti Bianca, Lukic Katarina, Stojanovic Maja, Stjepanovic Mihailo
Clinic for Infectious and Tropical Diseases, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
J Fungi (Basel). 2023 Nov 6;9(11):1084. doi: 10.3390/jof9111084.
Chronic pulmonary aspergillosis (CPA) is a chronic progressive lung disease associated with a poor prognosis and a 5-year mortality rate of approximately 40-50%. The disease is characterized by slowly progressive destruction of the lung parenchyma, in the form of multiple cavities, nodules, infiltrates or fibrosis. CPA can be challenging to diagnose due to its non-specific symptoms and similarities with other respiratory conditions combined with the poor awareness of the medical community about the disease. This can result in delayed treatment even for years and worsening of the patient's condition. Serological tests certainly play a significant role in diagnosing CPA but cannot be interpreted without radiological confirmation of CPA. Although many data are published on this hot topic, there is yet no single definitive test for diagnosing CPA, and a multidisciplinary approach which involves a combination of clinical picture, radiological findings, microbiological results and exclusion of other mimicking diseases, is essential for the accurate diagnosis of CPA.
慢性肺曲霉病（CPA）是一种慢性进行性肺部疾病，预后较差，5年死亡率约为40%-50%。该疾病的特征是肺实质以多个空洞、结节、浸润或纤维化的形式缓慢进行性破坏。由于其症状不具特异性，且与其他呼吸道疾病相似，再加上医学界对该疾病认识不足，CPA的诊断可能具有挑战性。这可能导致治疗延迟甚至数年，患者病情恶化。血清学检测在CPA诊断中确实发挥着重要作用，但没有CPA的影像学确认则无法进行解读。尽管关于这个热门话题已经发表了许多数据，但目前尚无单一的确诊CPA的检测方法，采用包括临床表现、影像学检查结果、微生物学结果以及排除其他类似疾病的多学科方法对于准确诊断CPA至关重要。
