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计算机辅助认知训练联合职业治疗对轻度认知障碍患者的干预:一项随机对照试验。

Intervention of computer-assisted cognitive training combined with occupational therapy in people with mild cognitive impairment: a randomized controlled trial.

作者信息

Wen Xin, Song Shangrong, Tian Hui, Cui Hang, Zhang Lijuan, Sun Yajie, Li Mingyue, Wang Yonghong

机构信息

The First Hospital of Jilin University, Changchun, Jilin, China.

School of Nursing, Jilin University, Changchun, Jilin, China.

出版信息

Front Aging Neurosci. 2024 May 10;16:1384318. doi: 10.3389/fnagi.2024.1384318. eCollection 2024.

DOI:10.3389/fnagi.2024.1384318
PMID:38832072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11146196/
Abstract

OBJECTIVE

Investigate the impact of combined computerized cognitive training and occupational therapy on individuals with mild cognitive impairment (MCI).

METHODS

We randomly assigned 118 MCI patients into two groups: a combined intervention group ( = 37) and a control group ( = 81), the latter receiving standard nursing care. The intervention group additionally underwent 12 weeks of computerized cognitive training and occupational therapy. Blind assessors evaluated cognitive performance, anxiety, depression, and daily living activities before the intervention, post-intervention, and at a 3-month follow-up.

RESULTS

Repeated-measures analysis of variance showed that the sMoCA scores, HAMA scores, and ADL scores of the experimental group at T2 (post-intervention) and T3 (3-month follow-up) were higher than those of the control group, and the difference was statistically significant ( < 0.001, < 0.001, = 0.026).

CONCLUSION

Computerized cognitive training combined with occupational therapy can improve patients' cognitive status, enhance their compliance with continuing care, and maintain their anxiety and self-care ability at a stable level.

CLINICAL TRIAL REGISTRATION

https://www.chictr.org.cn/index.html, identifier ChiCTR2200065014.

摘要

目的

探讨计算机化认知训练与职业治疗相结合对轻度认知障碍(MCI)患者的影响。

方法

我们将118例MCI患者随机分为两组:联合干预组(n = 37)和对照组(n = 81),后者接受标准护理。干预组额外接受了为期12周的计算机化认知训练和职业治疗。盲法评估人员在干预前、干预后和3个月随访时评估认知表现、焦虑、抑郁和日常生活活动。

结果

重复测量方差分析显示,实验组在T2(干预后)和T3(3个月随访)时的简易蒙特利尔认知评估量表(sMoCA)得分、汉密尔顿焦虑量表(HAMA)得分和日常生活活动能力(ADL)得分均高于对照组,差异有统计学意义(P < 0.001,P < 0.001,P = 0.026)。

结论

计算机化认知训练联合职业治疗可改善患者的认知状态,增强其对持续护理的依从性,并将其焦虑和自我护理能力维持在稳定水平。

临床试验注册

https://www.chictr.org.cn/index.html,标识符ChiCTR2200065014。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a0e/11146196/66b290e155da/fnagi-16-1384318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a0e/11146196/1d6aabeaf41d/fnagi-16-1384318-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a0e/11146196/404cb2694a32/fnagi-16-1384318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a0e/11146196/66b290e155da/fnagi-16-1384318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a0e/11146196/1d6aabeaf41d/fnagi-16-1384318-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a0e/11146196/404cb2694a32/fnagi-16-1384318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a0e/11146196/66b290e155da/fnagi-16-1384318-g003.jpg

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