Ismail Hira, Pathak Anjani Kumar, Lal Nand, Rastogi Pavitra, Ahmad Kaleem, Khan Mohd Aamir
Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, India.
Department of Biochemistry, King George's Medical University, Uttar Pradesh, Lucknow, India.
J Oral Biol Craniofac Res. 2024 Jul-Aug;14(4):430-434. doi: 10.1016/j.jobcr.2024.04.010. Epub 2024 May 24.
Visfatin, a pleotropic mediator mostly produced by visceral fat, is crucial in controlling the immunological and defensive systems. It serves the roles of a cytokine, an enzyme involved in energy metabolism, and a growth factor. The objective of the present study was to assess the impact of non-surgical periodontal therapy (scaling and root planing) on visfatin concentrations in saliva and gingival crevicular fluid in individuals with Periodontitis (stage-II grade-A).
54 individuals were divided into Group A (Periodontally Healthy) and Group B1(Periodontitis baseline) based on periodontal parameters including plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and radiographic parameters. After NSPT (SRP), Group B1 patients were recalled after 4 weeks, constituting Group B2 (post NSPT group B1). At baseline and 4 weeks after non-surgical periodontal therapy (SRP), all clinical parameters, salivary and GCF samples were recorded. An ELISA kit was used to measure the levels of visfatin. Using the paired -test, unpaired -test, and Pearson's correlation coefficient, data were analysed using SPSS 15.
After non-surgical periodontal treatment (SRP), the mean salivary and gingival crevicular fluid concentration of visfatin considerably decreased to a level comparable to periodontal health. In all groups, GCF visfatin concentration was higher than salivary concentration of visfatin. In periodontitis patients, visfatin concentration in GCF was 1.5 times higher than in saliva.
The results of this investigation suggest a direct correlation between salivary and gingival crevicular fluid visfatin concentration and periodontal tissue inflammation and disease activity.
内脂素是一种主要由内脏脂肪产生的多效性介质，在控制免疫和防御系统中起关键作用。它兼具细胞因子、参与能量代谢的酶以及生长因子的功能。本研究的目的是评估非手术牙周治疗（龈上洁治和根面平整）对Ⅱ期A级牙周炎患者唾液和龈沟液中内脂素浓度的影响。
根据包括菌斑指数（PI）、牙龈指数（GI）、探诊深度（PPD）、临床附着水平（CAL）和影像学参数在内的牙周参数，将54名个体分为A组（牙周健康组）和B1组（牙周炎基线组）。在进行非手术牙周治疗（龈上洁治和根面平整，SRP）后，B1组患者在4周后复诊，形成B2组（B1组非手术牙周治疗后组）。在非手术牙周治疗（SRP）的基线和4周后，记录所有临床参数、唾液和龈沟液样本。使用酶联免疫吸附测定（ELISA）试剂盒测量内脂素水平。使用配对t检验、非配对t检验和Pearson相关系数，采用SPSS 15对数据进行分析。
非手术牙周治疗（SRP）后，唾液和龈沟液中内脂素的平均浓度显著降低至与牙周健康相当的水平。在所有组中，龈沟液内脂素浓度均高于唾液内脂素浓度。在牙周炎患者中，龈沟液内脂素浓度比唾液中高1.5倍。
本研究结果表明，唾液和龈沟液内脂素浓度与牙周组织炎症和疾病活动之间存在直接相关性。
