Türer Çiğdem Coşkun, Balli Umut, Güven Berrak, Çetinkaya Burcu Özkan, Keleş Gonca Çayır
Department of Periodontology, Faculty of Dentistry, Bülent Ecevit University.
J Oral Sci. 2016;58(4):491-499. doi: 10.2334/josnusd.16-0116.
The purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group 1 comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzyme-linked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels. Furthermore, visfatin levels increased with inflammation and decreased following periodontal treatment. Our findings suggest that visfatin is an inflammatory biomarker of periodontal disease.(J Oral Sci 58, 491-499, 2016).
本研究的目的是评估牙周病不同阶段以及健康组织中的内脂素水平。此外，还研究了非手术牙周治疗对龈沟液和血清中内脂素水平的影响。根据临床和影像学检查结果，将45例患者分为三组。第1组为牙周健康个体（n = 15）；第2组为牙龈炎患者（n = 15）；第3组由重度慢性牙周炎患者（n = 15）组成。在治疗前以及治疗后1、3和6个月采集龈沟液和血清样本。采用酶联免疫吸附测定法测量内脂素水平。慢性牙周炎患者的龈沟液和血清内脂素水平高于牙龈炎患者或健康对照组（P < 0.016）。此外，牙龈炎组的内脂素水平高于健康对照组（P < 0.016）。非手术牙周治疗导致龈沟液和血清内脂素水平显著降低。此外，内脂素水平随炎症加重而升高，牙周治疗后降低。我们的研究结果表明，内脂素是牙周病的一种炎症生物标志物。（《口腔科学杂志》58卷，491 - 499页，2016年）
